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Identification of the substances present in red Brazilian propolis by UPLC-ESI-MS and NMR and evaluation of the antioxidant and antimicrobial activity of the isolated compounds

Grant number: 13/20313-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2014
Effective date (End): April 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Alexandra Christine Helena Frankland Sawaya
Grantee:Begona Gimenez-Cassina Lopez
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:10/51677-2 - Development of new mass spectrometry techniques and their general applications in science: chemistry, biochemistry, material sciences, forensics, medicine, food science, pharmaceutical and veterinary medicine, AP.TEM


Red propolis is a resinous product that bees produce and is typical of the northeastern states of Brazil. The compositiion of propolis composition varies widely depending on its botanical and geographical origin and on the bee involved in the collecting process. Different types of red propolis have been identified: group A presented the marker ion m/z 601.35 (C38H49O6) and includes samples from the states of Alagoas and Paraíba. Group B includes samples from Sergipe and Cuba, and presented a similar composition profile to the one of Dalbergia ecastophyllum, which has been identified as one of the botanical sources of red propolis. The ion markers of this group are m/z 255.06 (C15H11O4) - pinocembrin, m/z 267.06 (C16H11O4) - formononecin, m/z 271.06 (C15H11O5), m/z 271.10 (C16H11O4), m/z 283.06 (C16H11O5) - biochanin A, and m/z 301.07 (C16H13O6). The identification of the composition and the chemical structure of the ion markers by different techniques such as mass spectrometry and nuclear magnetic ressonance is important to standardize red propolis, since it has promising therapeutical properties and is a substance of interest for the food and pharmaceutical industry. It has antimicrobial, antioxidant, cytotoxic, analgesic, anti-inflammatory and liver protective activity, among others. Thus, not only the activity of propolis samples should be evaluated, but it is also indicated to evaluate the individual activity of the substances present in the sample to identify the bioactive compounds. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARNEIRO, M. J.; LOPEZ, B. G-C; LANCELLOTTI, M.; FRANCHI, G. C.; NOWILL, ALEXANDRE E.; SAWAYA, A. C. H. F.. Evaluation of the chemical composition and biological activity of extracts of Tetragonisca angustula propolis and Schinus terebinthifolius Raddi (Anacardiaceae). JOURNAL OF APICULTURAL RESEARCH, v. 55, n. 4, p. 315-323, . (15/06215-4, 13/20313-3, 08/58035-6)
MENDONCA-MELO, LUCYANA; MOTA, EVERTON; LOPEZ, BEGONA; SAWAYA, ALEXANDRA; FREITAS, LISIANE; JAIN, SONA; BATISTA, MARCUS; ARAUJO, EDILSON. Chemical and genetic similarity between Dalbergia ecastaphyllum and red propolis from the Northeastern Brazil. JOURNAL OF APICULTURAL RESEARCH, v. 56, n. 1, p. 32-39, . (13/20313-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LOPEZ, Begona Gimenez-Cassina. Chemical analysis of the bioactive compounds of red propolis. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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