|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||February 01, 2015|
|Effective date (End):||December 31, 2015|
|Field of knowledge:||Biological Sciences - Biophysics - Cellular Biophysics|
|Principal Investigator:||Manoel de Arcisio Miranda Filho|
|Grantee:||Estêvão Carlos Lima|
|Home Institution:||Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil|
The superfamily of Kir ion channels, Inward-rectifier potassium ion channels, has importance in many physiological and pathological processes. This ion channels are greatly expressed in neural and cardiac, skeletal and smooth muscle cells. It has already been demonstrated in the literature that the subfamily 6.2; i.e. Kir6.2, is regulated by the regulatory subunit SUR - sulphonylurea receptor, but there is no citations of SUR regulation over other Kir subfamilies. Then on, the present project has as objective the evaluation of the possible modulatory effects of the receptor SUR1 and SUR2A over Kir2.6 and Kir2.2 ion channels subfamilies.