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Electrophysiological analysis of gating mechanisms of Inward-rectifier potassium ion channels (Kir).

Grant number: 14/24643-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2015
Effective date (End): December 31, 2015
Field of knowledge:Biological Sciences - Biophysics - Cellular Biophysics
Principal Investigator:Manoel de Arcisio Miranda Filho
Grantee:Estêvão Carlos Lima
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The superfamily of Kir ion channels, Inward-rectifier potassium ion channels, has importance in many physiological and pathological processes. This ion channels are greatly expressed in neural and cardiac, skeletal and smooth muscle cells. It has already been demonstrated in the literature that the subfamily 6.2; i.e. Kir6.2, is regulated by the regulatory subunit SUR - sulphonylurea receptor, but there is no citations of SUR regulation over other Kir subfamilies. Then on, the present project has as objective the evaluation of the possible modulatory effects of the receptor SUR1 and SUR2A over Kir2.6 and Kir2.2 ion channels subfamilies.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, DEBORA E. S.; CALI, MARIANA P.; PAZIN, WALLANCE M.; CARLOS-LIMA, ESTEVAO; SALLES TREVISAN, MARIA TERESA; VENANCIO, TIAGO; ARCISIO-MIRANDA, MANOEL; ITO, AMANDO S.; CARLOS, ROSE M. Luminescent Ru(II) Phenanthroline Complexes as a Probe for Real-Time Imaging of A beta Self-Aggregation and Therapeutic Applications in Alzheimer's Disease. Journal of Medicinal Chemistry, v. 59, n. 19, p. 9215-9227, OCT 13 2016. Web of Science Citations: 7.

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