| Grant number: | 14/24556-0 |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| Start date: | May 01, 2015 |
| End date: | April 30, 2016 |
| Field of knowledge: | Biological Sciences - Microbiology - Applied Microbiology |
| Principal Investigator: | Itamar Soares de Melo |
| Grantee: | Suikinai Nobre Santos |
| Supervisor: | Paul Frederick Long |
| Host Institution: | Embrapa Meio-Ambiente. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). Jaguariúna , SP, Brazil |
| Institution abroad: | King's College London, England |
| Associated to the scholarship: | 13/16037-0 - Isolation and characterization of genes correlated to biosynthesis of antitumor molecules in Streptomyces sp., BP.PD |
Abstract Complex polyketides are microbial natural products (including clinically-useful medicines) whose chemical structures correlate with the sequence of the modular enzymes responsible for their biosynthesis. This unique paradigm means that the structure of the gene can be inferred from the chemical structure of the molecule, and (with less certainty) the reverse is true. Now, genome-scale sequencing of actinomycetes has revealed untapped chemical diversity in culturable Streptomycetes: there are many biosynthetic clusters present but most are cryptic (silent). Expression of biosynthetic genes is now a severe bottleneck in trying to develop a genuine synthetic biology of natural products, in which PKSs are designed and fabricated to order to produce a specificed target molecule. According to preliminary studies of the analysis of the genome of strain model in this study, CCMA/Caat52 is a new species of Streptomyces and poor knowledge of gene blocks biosynthetic pathways responsible for the production of phenazinas by actinobacteria, then this project aims to research on the discovery and determination of genes (PKS and NRPS) responsible for producing biosynthetic pathways of phenazinas. The information and training will be very useful in the search for consolidation line of research in microbial bioprospecting using the discovery of genes related to the biosynthesis of secondary metabolites and sequencing of the entire genome of Streptomyces sp. Environmental Microbiology Laboratory at Embrapa Environment. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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