Heart rate variability and cardiorespiratory coupling in the coexistence of chronic obstructive pulmonary disease associated with obstructive sleep apnea

• Grant number: 13/23013-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2015
• End date: June 30, 2016
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Audrey Borghi Silva
• Grantee: Renata Trimer
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Background: Several studies have investigated the deleterious effects of the association between obstructive sleep apnea (OSA) with obstructive lung diseases (OLD), which include greater severity of hypoxemia cause hemodynamic impairment, evaluated during sleep and wakefulness, which negatively impact on morbidity and mortality. However, is little known if the coexistence of respiratory disease and OSA are associated with greater impairment in autonomic and cardio respiratory coupling during wakefulness and sleep , which has been powerful diagnostic and prognostic markers. Objectives: To assess autonomic behavior through the analysis of heart rate variability (HRV) , the oxygen saturation variability (OSV) and cardio respiratory synchronization during wakefulness and different sleep stages in patients with coexistence of OLD and OSA .Study Design: Cross-sectional, observational, comparative. Methods: 20 patients with COPD and OSA, 20 patients with asthma and OSA, 20 patients with OSA without respiratory diseases. Be obtained through polysomnography signals of heart rate, beat to beat and respiratory cycles, in wakefulness and during sleep. HRV linear and nonlinear indices, OSV and cardio respiratory coupling are calculated during wakefulness and the different sleep stages, and after this data will be correlated with clinical parameters and severity of OSA.Relevance of the study: The analysis of HRV, OSV and cardio respiratory coupling in patients with coexistence of OLD and OSA will provide greater understanding of the impact of these adjustments in cardio respiratory diseases modulated by autonomic control , and thus establish the relationship between the severity of coexistence OSA and OLD .

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRÉA L.G. DA SILVA; CÁSSIA L. GOULART; KAMILA M.K. MANSOUR; GUILHERME D. BACK; RAMONA CABIDDU; RENATA TRIMER; AUDREY BORGHI-SILVA. Acute effects of expiratory positive pressure on autonomic cardiac modulation during spontaneous and slow deep breathing in COPD patients. Anais da Academia Brasileira de Ciências, v. 92, n. 2, 2020-07-20. (15/04101-1, 13/23013-0)

CABIDDU, RAMONA; BORGHI-SILVA, AUDREY; TRIMER, RENATA; TRIMER, VITOR; RICCI, PAULA ANGELICA; MONTEIRO, CLARA ITALIANO; MAGALHAES MANIGLIA, MARCELA CAMARGO; PEREIRA, ANA MARIA SILVA; DAS CHAGAS, GUSTAVO RODRIGUES; CARVALHO, ELIANE MARIA. Hippotherapy acute impact on heart rate variability non-linear dynamics in neurological disorders. Physiology & Behavior, v. 159, p. 88-94, MAY 15 2016. (13/23013-0)

SILVA, ANDREA L. G.; GOULART, CASSIA L.; MANSOUR, KAMILA M. K.; BACK, GUILHERME D.; CABIDDU, RAMONA; TRIMER, RENATA; BORGHI-SILVA, AUDREY. Acute effects of expiratory positive pressure on autonomic cardiac modulation during spontaneous and stow deep breathing in COPD patients. Anais da Academia Brasileira de Ciências, v. 92, n. 2, 2020. (13/23013-0, 15/04101-1)

CABIDDU, RAMONA; TRIMER, RENATA; MAZZUCO, ADRIANA; BORGHI E SILVA, AUDREY. Influence of reduced airway patency and respiratory muscle strength on autonomic cardiac modulation in COPD patients. European Respiratory Journal, v. 48, p. 2-pg., 2016-09-01. (13/23013-0)

DA LUZ GOULART, CASSIA; SIMON, JULIO CRISTIANO; SCHNEIDERS, PALOMA DE BORBA; SAN MARTIN, ELISABETE ANTUNES; CABIDDU, AMONA; BORGHI-SILVA, AUDREY; TRIMER, RENATA; GONCALVES DA SILVA, ANDREA LUCIA. Respiratory muscle strength effect on linear and nonlinear heart rate variability parameters in COPD patients. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 11, p. 7-pg., 2016-01-01. (13/23013-0)

GOULART, CASSIA DA LUZ; CABIDDU, RAMONA; SCHNEIDERS, PALOMA DE BORBA; SAN MARTIN, ELISABETE ANTUNES; TRIMER, R. ENATA; BORGHI-SILVA, AUDREY; GONCALVES DA SILVA, ANDREA LUCIA. Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients?. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 12, p. 849-857, 2017. (13/23013-0)

DA LUZ GOULART, CASSIA; SIMON, JULIO CRISTIANO; SCHNEIDERS, PALOMA DE BORBA; SAN MARTIN, ELISABETE ANTUNES; CABIDDU, AMONA; BORGHI-SILVA, AUDREY; TRIMER, RENATA; GONCALVES DA SILVA, ANDREA LUCIA. Respiratory muscle strength effect on linear and nonlinear heart rate variability parameters in COPD patients. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 11, p. 1671-1677, 2016. (13/23013-0)

TRIMER, RENATA; CABIDDU, RAMONA; MENDES, RENATA GONCALVES; COSTA, FERNANDO SOUZA MELO; OLIVEIRA JUNIOR, ANTONIO DELFINO; BIANCHI, ANNA MARIA; BORGHI-SILVA, AUDREY. Association between COPD and OSA: impact on cardiorespiratory dynamics during sleep. European Respiratory Journal, v. 50, p. 1-pg., 2017-09-01. (13/23013-0, 15/04101-1)

GOULART, CASSIA DA LUZ; CABIDDU, RAMONA; SCHNEIDERS, PALOMA DE BORBA; SAN MARTIN, ELISABETE ANTUNES; TRIMER, R. ENATA; BORGHI-SILVA, AUDREY; GONCALVES DA SILVA, ANDREA LUCIA. Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients?. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 12, p. 9-pg., 2017-01-01. (13/23013-0)