The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals.

• Grant number: 14/23196-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2015
• End date: April 30, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rodolfo de Paula Vieira
• Grantee: Breanne Mackenzie
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
• Associated research grant: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals, AP.JP

Abstract

Asthma is a chronic airway inflammatory disease that results in impairment of quality of life of asthmatic individuals. In the last years, several studies have shown that the aerobic physical training (APT) performed at proper intensity and volume present anti-inflammatory effects to the airways, both in experimental models of asthma as to asthmatic individuals. However, although few cellular effects of have been investigated (only in experimental studies), the study of possible mediators (intra and extracellular) involved in the effects of APT in asthma was not yet investigated. Thus, the present project will evaluate the number of total and differential cells in the induced sputum, the expression of purinergic receptors and of proteins SOCS, JAKs and STATs in the cells of induced sputum of asthmatic patients submitted to APT, the levels of inflammatory mediators in the supernatants of induced sputum and/or in the breath condensate. Furthermore, the antigen presentation by dendritic cells to CD4+ T lymphocytes from the peripheral blood of asthmatic patients submitted to APT also will be evaluated. In addition, the proliferation and in vitro cytokines production by CD4+ T lymphocytes from the peripheral blood of asthmatic patients submitted to APT will be evaluated.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRADE-SOUSA, ADILSON SANTOS; PEREIRA, PAULO ROGERIO; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ASSUMPCAO-NETO, ERASMO; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; PEREIRA VELOSA, ANA PAULA; TEODORO, WALCY ROSOLIA; et al. Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One, v. 11, n. 9, SEP 27 2016. (12/15165-2, 14/14604-8, 14/23196-0, 12/51464-4)

PEREIRA, PAULO ROGERIO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; DAVINO CHIOVATTO, JAIME EDUARDO; MATOS, YVES; GREIFFO, FLAVIA REGINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRUGEMMAN, THAYSE REGINA; DELLE, HUMBERTO; IDZKO, MARCO; et al. Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 7, p. 1276-1284, JUL 2016. (12/15165-2, 14/23196-0, 14/14604-8, 12/51464-4)

ALBERCA-CUSTODIO, RICARDO WESLEY; GREIFFO, FLAVIA REGINA; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ANDRADE-SOUSA, ADILSON SANTOS; GRAUDENZ, GUSTAVO SILVEIRA; GOMES SANTOS, ANGELA BATISTA; DAMACENO-RODRIGUES, NILSA REGINA; CASTRO-FARIA-NETO, HUGO CAIRE; ARANTES-COSTA, FERNANDA MAGALHAES; et al. Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway. FRONTIERS IN IMMUNOLOGY, v. 7, JUN 14 2016. (12/15165-2, 14/23196-0, 13/23763-0, 12/23305-9, 14/14604-8, 12/21519-1, 14/09292-7)

RIGONATO-OLIVEIRA, NICOLE CRISTINE; MACKENZIE, BREANNE; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DELLE, HUMBERTO; COSTA-GUIMARAES, TAMARA; DAMACENO-RODRIGUES, NILSA REGINA; DULLEY, LARISSA HILARIO; et al. Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells. EXERCISE IMMUNOLOGY REVIEW, v. 24, p. 48-56, 2018. (12/25435-7, 12/15165-2, 14/23196-0, 12/24880-7)

DURIGON, THOMAS STRAVINSKAS; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; DE ANGELIS, KATIA; MALFITANO, CHRISTIANO; DA PALMA, RENATA KELLY; GUERRA, JULIANA MORENO; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; et al. Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. JOURNAL OF INNATE IMMUNITY, v. 10, n. 4, p. 279-290, 2018. (12/16498-5, 16/08280-0, 12/15165-2, 14/23196-0, 12/23305-9, 14/14604-8)

SANTOS-DIAS, ALANA; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MOYSES, ROSA MARIA; CONSOLIM-COLOMBO, FERNANDA MARCIANO; VIEIRA, RODOLFO PAULA. Longevity protein klotho is induced by a single bout of exercise. BRITISH JOURNAL OF SPORTS MEDICINE, v. 51, n. 6, MAR 2017. (14/14604-8, 14/23196-0, 12/15165-2)

DAVINO-CHIOVATTO, JAIME EDUARDO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; SANTOS-DIAS, ALANA; ALMEIDA-OLIVEIRA, ANA ROBERTA; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; BRITO, AURILEIA APARECIDA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; DAMACENO-RODRIGUES, NILSA REGINA; LIGEIRO OLIVEIRA, ANA PAULA; et al. Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation. ARCHIVOS DE BRONCONEUMOLOGIA, v. 55, n. 11, p. 573-580, NOV 2019. (12/15165-2, 14/23196-0, 14/14604-8, 14/07500-1, 14/12755-9)