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Bulbar raphe role in active expiration modulation during hypercapnia in different arousal states (sleep and wakefulness)

Grant number: 15/04926-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2015
Effective date (End): April 30, 2016
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal researcher:Glauber dos Santos Ferreira da Silva
Grantee:Carlos Aparecido da Silva Junior
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:13/17606-9 - Serotonin and respiratory control in vertebrates, AP.JP


Serotonin (5-HT) has been described for several years and is widely present in several classes of animals. In mammals, the active expiration has been focus of intense research in respiratory control field. It has been demonstrated that the recruitment of expiratory activity (expiratory muscles, ex: abdominal) originates from an expiratory oscillator (RTN / pFRG), distinct from the inspiratory one (pre-Bötzinger), being recruited in high respiratory demand conditions, such as during hypercapnia. Despite advances in knowledge about breathing control, there are few studies on the motor and respiratory control related to the activity of the abdominal muscles (expiration). There are no studies in the literature addressing neural mechanisms involved in this activity, especially 5-HT neurons of the bulbar raphe, which are strongly involved in the respiratory control network, especially in respiratory adjustment during hypercapnia. Therefore, the objective of the present project is to assess the effect of chemical inhibition (muscimol) of the medullary raphe during hypercapnia, as well as the inhibition of 5-HT neurons (8-OH-DPAT) in the medullary raphe during active expiration in hypercapnic conditions during wakefulness and sleep.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEIRAO, ISABELA P.; SILVA, CARLOS A.; GARGAGLIONI, LUCIANE H.; DA SILVA, GLAUBER S. F.. Hypercapnia-induced active expiration increases in sleep and enhances ventilation in unanaesthetized rats. JOURNAL OF PHYSIOLOGY-LONDON, v. 596, n. 15, p. 3271-3283, . (13/17606-9, 16/11061-9, 14/12190-1, 15/04926-0)

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