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Medullary raphe and active expiration during hypercapnia: role of serotonergic modulation

Grant number: 17/10868-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Glauber dos Santos Ferreira da Silva
Grantee:Isabela de Paula Leirão
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:13/17606-9 - Serotonin and respiratory control in vertebrates, AP.JP

Abstract

In the nervous system, serotonin (5-HT) is involved in several functions, including circadian rhythms, diet, emotional state, control of sleep and respiratory control. Respiration is a rhythmic process initiated in the central nervous system (CNS). At rest, expiration is a passive process, however, mammals recruit expiratory muscles (such as abdominal) under conditions of increased respiratory drive, such as during hypercapnia. Studying active expiration is critical, as it is activated under conditions essential to generate forced expiration. It also may be involved in pathological conditions. Studies have suggested that the RTN/pFRG is the main generator site of this activity. There are few studies on motor control and respiratory-related activity of the abdominal muscles (expiration), and there is no description of any other brainstem regions that may modulate this activity. In particular, medullary raphe 5-HT neurons, which are involved in the central CO2/pH chemoreception, since hypercapnia is a condition in which active expiration is present. The medullary raphe 5-HT neurons are considered to be an important component of CO2/pH chemoreception and through excitatory projections to RTN may influence and modulate active expiration. This type of serotonergic modulation on active expiration during hypercapnia has never been demonstrated, particularly in non-anesthetized animals and during sleep and wakefulness. Different methodology will be used, such as: EEG, EMG and reverse microdialysis. (AU)