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Active expiration and sleep-wake cycle: participation of medullary raphe

Grant number: 16/11061-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2016
Effective date (End): June 30, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Glauber dos Santos Ferreira da Silva
Grantee:Isabela de Paula Leirão
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:13/17606-9 - Serotonin and respiratory control in vertebrates, AP.JP


In mammals, active expiration has been focus of intense research in respiratory control field. It has been demonstrated that the recruitment of expiratory activity (expiratory muscles, ex: abdominal) originates from an expiratory oscillator (RTN / pFRG), distinct from the inspiratory one (pre-Bötzinger), being recruited in high respiratory demand conditions, such as during hypercapnia. Despite advances in knowledge about breathing control, there are few studies on the motor and respiratory control related to the activity of the abdominal muscles (expiration). There are no studies in the literature addressing neural mechanisms involved in this activity, especially 5-HT neurons of the bulbar raphe, which are strongly involved in the respiratory control network, especially in respiratory adjustment during hypercapnia. Therefore, the objective of the present project is to assess the effect of chemical inhibition (muscimol) of the medullary raphe during hypercapnia, as well as the inhibition of 5-HT neurons (8-OH-DPAT) in the medullary raphe during active expiration in hypercapnic conditions during wakefulness and sleep. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEIRAO, ISABELA P.; ZOCCAL, DANIEL B.; GARGAGLIONI, LUCIANE H.; DA SILVA, GLAUBER S. F. Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 472, n. 11 SEP 2020. Web of Science Citations: 1.
LEIRAO, ISABELA P.; SILVA, CARLOS A.; GARGAGLIONI, LUCIANE H.; DA SILVA, GLAUBER S. F. Hypercapnia-induced active expiration increases in sleep and enhances ventilation in unanaesthetized rats. JOURNAL OF PHYSIOLOGY-LONDON, v. 596, n. 15, p. 3271-3283, AUG 1 2018. Web of Science Citations: 5.

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