Carbapenemases detection and identification in Klebsiella pneumoniae isolates from patients admitted to a University Hospital of Paraná State, Brazil

• Grant number: 15/10403-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2015
• End date: December 31, 2016
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: André Pitondo da Silva
• Grantee: Guilherme Bartolomeu Gonçalves
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 13/22581-5 - Study of pathogenic mechanisms and correlation with antimicrobial resistance of Klebsiella pneumoniae from Brazil and other countries across five continents, AP.JP

Abstract

Carbapenemase-producing bacteria, especially Klebsiella pneumoniae strains, have been commonly associated with hospital outbreaks, leading to high mortality due to few therapeutic options available for admitted patients. Therefore, studies investigating the prevalence and types of carbapenemases in Klebsiella pneumoniae from distinct Brazilian regions are extremely relevant. The aim of this study is to investigate the presence of carbapenemases in K. pneumoniae isolated from patients hospitalized at a university hospital of Paraná State, Brazil, as well as characterizing the genetic relationship among the isolates by ERIC-PCR. (AU)