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Processes intensification of lignocellulosic biorefineries integrating ethanol and xylitol production steps from sugarcane bagasse in fluidized bed bioreactor

Grant number: 14/27055-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2015
Effective date (End): October 31, 2018
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Silvio Silvério da Silva
Grantee:Felipe Antonio Fernandes Antunes
Home Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil


In this project it is proposed to evaluate the processes intensification using a single reactor to obtain fermentable sugars from sugarcane bagasse and its fermentation into biomolecules, such as ethanol and xylitol. It will be used reactor of column operated in fluidized bed configuration in order to perform, in sequence, the steps of pretreatment, enzymatic hydrolysis and fermentation to produce ethanol and xylitol. Different conditions of alkaline and acid pretreatment of sugarcane bagasse in fluidized bed reactor will be evaluated separately using statistical design of experiments for determining conditions of each process. Sequentially, it will be performed separately saccharification of the remaining fractions of sugarcane bagasse corresponding the best conditions for each pretreatment operation, in order to use the cellulosic and hemicellulosic fractions of biomass in the fermentative process. After the saccharification, it will be used the yeast S. shehatae. UFMG 52.2, native C5 and C6 sugars fermenting to produce ethanol, and the yeast and C. guilliermondii FTI 20037, to xylitol production, both biomolecules produced in separate processes. Aiming a better understanding of the structural change of biomass among the pretreatment steps of biomass in fluidized bed reactor, the fractions of biomass will be structurally characterized using physicochemical techniques such as SEM; Raman spectroscopy, FTIR and FT-NIR. It is expected by this project to obtain results that strengthen the technology of biotechnological processes for ethanol and xylitol production from sugarcane bagasse in fluidized bed reactor, establishing important variables in an innovative fermentation process that will contribute to the development Brazilian biorefineries.

Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDES ANTUNES, FELIPE ANTONIO; CHANDEL, ANUJ KUMAR; TERAN-HILARES, RULY; INGLE, AVINASH P.; RAI, MAHENDRA; DOS SANTOS MILESSI, THAIS SUZANE; DA SILVA, SILVIO SILVERIO; DOS SANTOS, JULIO CESAR. Overcoming challenges in lignocellulosic biomass pretreatment for second-generation (2G) sugar production: emerging role of nano, biotechnological and promising approaches. 3 BIOTECH, v. 9, n. 6 JUN 2019. Web of Science Citations: 0.
INGLE, AVINASH P.; CHANDEL, ANUJ K.; ANTUNES, FELIPE A. F.; RAI, MAHENDRA; DA SILVA, SILVIO S. New trends in application of nanotechnology for the pretreatment of lignocellulosic biomass. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, v. 13, n. 3, p. 776-788, MAY-JUN 2019. Web of Science Citations: 0.
MUSO CACHUMBA, J. J.; TERAN HILARES, R.; BRUMANO, L. P.; MARCELINO, P. R. F.; ANTUNES, F. A. F.; SANTOS, J. C.; DA SILVA, S. S. Extracellular L-asparaginase production in solid-state fermentation by using sugarcane bagasse as support material. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, v. 49, n. 4, p. 328-333, APR 21 2019. Web of Science Citations: 0.
ANTUNES, F. A. F.; SANTOS, J. C.; CHANDEL, A. K.; CARRIER, D. J.; PERES, G. F. D.; MILESSI, T. S. S.; DA SILVA, S. S. Repeated batches as a feasible industrial process for hemicellulosic ethanol production from sugarcane bagasse by using immobilized yeast cells. Cellulose, v. 26, n. 6, p. 3787-3800, APR 2019. Web of Science Citations: 0.
ANTUNES, F. A. F.; CHANDEL, A. K.; BRUMANO, L. P.; TERAN HILARES, R.; PERES, G. F. D.; AYABE, L. E. S.; SORATO, V. S.; SANTOS, J. R.; SANTOS, J. C.; DA SILVA, S. S. A novel process intensification strategy for second-generation ethanol production from sugarcane bagasse in fluidized bed reactor. RENEWABLE ENERGY, v. 124, n. SI, p. 189-196, AUG 2018. Web of Science Citations: 6.
ISAAC, AUGUSTA; ANTUNES, FELIPE A. F.; CONTI, RODOLFO; MONTORO, LUCIANO ANDREY; MALACHIAS, ANGELO; MASSARA, PATRICIA; KITTEN, GREGORY; MARKOETTER, HENNING; MANKE, INGO; DA SILVA, SILVIO SILVERIO. Unveiling 3D physicochemical changes of sugarcane bagasse during sequential acid/alkali pretreatments by synchrotron phase-contrast imaging. INDUSTRIAL CROPS AND PRODUCTS, v. 114, p. 19-27, APR 2018. Web of Science Citations: 1.
BRUMANO, LARISSA PEREIRA; FERNANDES ANTUNES, FELIPE ANTONIO; SOUTO, SARA GALENO; DOS SANTOS, JULIO CESAR; VENUS, JOACHIM; SCHNEIDER, ROLAND; DA SILVA, SILVIO SILVERIO. Biosurfactant production by Aureobasidium pullulans in stirred tank bioreactor: New approach to understand the influence of important variables in the process. Bioresource Technology, v. 243, p. 264-272, NOV 2017. Web of Science Citations: 8.
ANTUNES, FELIPE A. F.; CHANDEL, ANUJ K.; DOS SANTOS, JULIO CESAR; MILESSI, THAIS S. S.; PERES, GUILHERME F. D.; DA SILVA, SILVIO SILVERI. Hemicellulosic Ethanol Production in Fluidized Bed Reactor from Sugar Cane Bagasse Hydrolysate: Interplay among Carrier Concentration and Aeration Rate. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 5, n. 9, p. 8250-8259, SEP 2017. Web of Science Citations: 2.
SAHA, KOEL; DASGUPTA, JHILLY; CHAKRABORTY, SUDIP; FERNANDES ANTUNES, FELIPE ANTONIO; SIKDER, JAYA; CURCIO, STEFANO; DOS SANTOS, JULIO CESAR; ARAFAT, HASSAN A.; DA SILVA, SILVIO SILVERIO. Optimization of lignin recovery from sugarcane bagasse using ionic liquid aided pretreatment. Cellulose, v. 24, n. 8, p. 3191-3207, AUG 2017. Web of Science Citations: 12.
MUSO CACHUMBA, JORGE JAVIER; FERNANDES ANTUNES, FELIPE ANTONIO; DIAS PERES, GUILHERME FERNANDO; BRUMANO, LARISSA PEREIRA; DOS SANTOS, JULIO CESAR; DA SILVA, SILVIO SILVERIO. Current applications and different approaches for microbial L-asparaginase production. Brazilian Journal of Microbiology, v. 47, n. 1, p. 77-85, DEC 2016. Web of Science Citations: 23.
JORGE JAVIER MUSO CACHUMBA; FELIPE ANTONIO FERNANDES ANTUNES; GUILHERME FERNANDO DIAS PERES; LARISSA PEREIRA BRUMANO; JÚLIO CÉSAR DOS SANTOS; SILVIO SILVÉRIO DA SILVA. Current applications and different approaches for microbial L-asparaginase production. Brazilian Journal of Microbiology, v. 47, p. 77-85, Dez. 2016.

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