Morphology and MMP-9, AR and IFGR-1 evaluation on the anterior prostate lobe of the aging mice (FVB) submitted to hyperlipidic diet and treated with Jaboticaba peel extract

• Grant number: 15/24793-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2016
• End date: December 31, 2016
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Valéria Helena Alves Cagnon Quitete
• Grantee: Marjorie Barcha Longo
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Aging is a very important factor on prostate morphological and functional alterations. And also, obesity and/or overweight, are factors involved in promoting metabolic changes, contributing to occurrence of prostate damages. Currently altenative methods, using natural products, have been evaluated as prostate injury treatment. The Jaboticaba has been studied due to possible antioxidant and anti-inflammatory activity, besides having showed positive effects on the hormonal regulation and the reduction of the weight gain. Therefore, the main objective of this study will be to evaluate the effects of aging and hyperlipidic diet on the structural and molecular biology of the anterior prostate lobe (coagulation gland) of FVB mice. And also, to verify the effect of the Jaboticaba peel extract (ECJ) treatment in these same mice. For this, it will be used 50 FVB mice distributed in 5 experimental groups: JV (Young), SE (Senescent), SHP (Senescent + Hyperlipidic diet), SJ (Senescent + ECJ treatment) and SHJ (Senescent +Hyperlipidic diet+ ECJ treatment). After 60 days of treatment, the animals will be sacrificed and the anterior prostate lobe will be collected. Finally, the anterior prostate lobe will be analyzed by means of histopathological analysis with light microscopy, and AR, IFGR-1 and MMP-9 immunostochemical methods.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LONGO, MARJORIE BARCHA; LAMAS, CELINA DE ALMEIDA; ROSSETTO, ISABELA URRA; NOGUEIRA-LIMA, ELLEN; COLLARES-BUSATTO, CARLA BEATRIZ; MAROSTICA JUNIOR, MARIO ROBERTO; ALVES CAGNON QUITETE, VALERIA HELENA. Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.. Brazilian Archives of Biology and Technology, v. 66, p. 12-pg., 2023-01-01. (15/25714-1, 15/13320-9, 18/11069-5, 15/24793-5, 18/04579-7, 15/50333-1)