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Morphology and MMP-9, AR and IFGR-1 evaluation on the anterior prostate lobe of the aging mice (FVB) submitted to hyperlipidic diet and treated with Jaboticaba peel extract

Grant number: 15/24793-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2016
Effective date (End): December 31, 2016
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal researcher:Valéria Helena Alves Cagnon Quitete
Grantee:Marjorie Barcha Longo
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Aging is a very important factor on prostate morphological and functional alterations. And also, obesity and/or overweight, are factors involved in promoting metabolic changes, contributing to occurrence of prostate damages. Currently altenative methods, using natural products, have been evaluated as prostate injury treatment. The Jaboticaba has been studied due to possible antioxidant and anti-inflammatory activity, besides having showed positive effects on the hormonal regulation and the reduction of the weight gain. Therefore, the main objective of this study will be to evaluate the effects of aging and hyperlipidic diet on the structural and molecular biology of the anterior prostate lobe (coagulation gland) of FVB mice. And also, to verify the effect of the Jaboticaba peel extract (ECJ) treatment in these same mice. For this, it will be used 50 FVB mice distributed in 5 experimental groups: JV (Young), SE (Senescent), SHP (Senescent + Hyperlipidic diet), SJ (Senescent + ECJ treatment) and SHJ (Senescent +Hyperlipidic diet+ ECJ treatment). After 60 days of treatment, the animals will be sacrificed and the anterior prostate lobe will be collected. Finally, the anterior prostate lobe will be analyzed by means of histopathological analysis with light microscopy, and AR, IFGR-1 and MMP-9 immunostochemical methods.

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