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A study of macrophages M1 and M2 in the progression of emphysema in animals exposed to fine particulate matter (PM 2.5) from diesel exhaust

Grant number: 15/19751-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2016
Effective date (End): February 28, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Grantee:Alyne Riani Moreira
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Macrophages are cell types involved in the progression of pulmonary emphysema and can take on different functions, depending on the stimuli they receive and the microenvironment. In the presence of interferon-³ (IFN-³) is the activation of macrophages M1, recognized as a pro-inflammatory. However in the presence of interleukin-4 (IL-4) and -13 (IL-13) is the alternative activation of macrophages M2 type recognized by exert anti-inflammatory action and good phagocytic action to microorganisms and apoptotic cells (eferocitose). Considerando the progression of emphysema is associated with a reduction of the activity eferocitose and pulmonary response in the presence of pollutants depends on the effective actions of macrophages to eliminate such particles, it is important to check the involvement of the different phenotypes of macrophages involved in emphysema development process in mice undergoing pollutants. For mice receive both the intranasal instillation of elastase induced emphysema, and for the controls groups receive saline and are exposed to polluted air, or filtered according to the separation of groups. We assess respiratory function, hemodynamic parameters, inflammatory profile in BAL, evaluating the mean linear intercept and proportions of elastic and collagen fibers in the parenchyma. We will evaluate the expression of cytokines IL-12, IFN-³, IL-4, IL-10 and IL-13 by ELISA in lung homogenate. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MOREIRA, Alyne Riani. Study of the role of M1 and M2 macrophages in the development of emphysema in animals exposed to fine particles (PM 2.5) from diesel exhaust. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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