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Metabolomic characterization of blood and meat from young Nellore bulls, progeny of bulls with different EPDs for growth, precocity and muscularity

Grant number: 16/01320-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2016
Effective date (End): June 30, 2020
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Production
Principal researcher:Saulo da Luz e Silva
Grantee:Nara Regina Brandão Cônsolo
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Associated scholarship(s):18/09800-3 - Metabolomics characterization of sheep and cattle meat, BE.EP.PD

Abstract

The need for improved the animal production and profitability has generated great search for technologies that provide better results for producers and industry. In this sense, in order to improve beef efficiency production, genetic selection tools, such as expected progeny differences (EPDs), has shown as a good alternative to improve economic traits in the herd, increasing the animal performance, carcass muscularity, improving the subprimal cuts yield, and increasing precocity. Therefore, the aim of this study is to analyze the blood and meat metabolomics profile from young bulls Nellore, progeny of bulls selected for high and low EPDs for animal growth, precocity, and muscularity, founding some metabolites responsible for the traits evaluated and the metabolic pathways involved in the process in order to identify possible markers metabolites. Ninety-six young bulls, 14 month old and 350kg of body weight will be used. The animals are from commercial herd that use genetic selection, and will separated into the following groups: high and low EPDs for animal growth, precocity, and muscularity, with 16 animals/group. The animals will be fed with the same diet. The performance and muscularity will be evaluates with weighing and ultrasound measures. For metabolomics profile, blood samples will be taken at the beginning and at the end of feedlot, meat samples will be taken from Longissimus muscle at 24 hours after slaughter. The blood and meat metabolites will be identify and quantify by nuclear resonance magnetic (RMN). Then the metabolic pathways will be designed by IPA software, from metabolites involved with the evaluated traits.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CONSOLO, NARA R. B.; SILVA, JULIANA; BUARQUE, VICENTE M.; BARBOSA, LUIS C.; PADILLA, ANGEL H.; COLNAGO, LUIZ A.; NETTO, ARLINDO SARAN; GERRARD, DAVID E.; SILVA, SAULO L. Metabolomic signature of genetic potential for muscularity in beef cattle. ANIMAL BIOTECHNOLOGY, MAY 2021. Web of Science Citations: 0.
CONSOLO, N. R. B.; BUARQUE, V. L. M.; SILVA, J.; POLETI, M. D.; BARBOSA, L. C. G. S.; HIGUERA-PADILLA, A.; GOMEZ, J. F. M.; COLNAGO, L. A.; GERRARD, D. E.; NETTO, A. SARAN; SILVA, S. L. Muscle and liver metabolomic signatures associated with residual feed intake in Nellore cattle. ANIMAL FEED SCIENCE AND TECHNOLOGY, v. 271, JAN 2021. Web of Science Citations: 0.
CONSOLO, NARA R. B.; OLIVECRONA, NATALIA; SAMUELSSON, LINDA M.; REIS, MARIZA G.; EDWARDS, PATRICK J. B.; REIS, MARLON M. Investigation of metabolites associated with confinement odour in chilled vacuum-packed lamb by proton nuclear magnetic resonance (H-1 NMR) spectroscopy. MEAT SCIENCE, v. 169, NOV 2020. Web of Science Citations: 0.
BRANDAO CONSOLO, NARA REGINA; DA SILVA, JULIANA; MACEDO BUARQUE, VICENTE LUIZ; HIGUERA-PADILLA, ANGEL; GARIBALDI SIMON BARBOSA, LUIS CARLOS; ZAWADZKI, ANDRESSA; COLNAGO, LUIS ALBERTO; NETTO, ARLINDO SARAN; GERRARD, DAVID EDWIN; SILVA, SAULO LUZ. Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle. METABOLITES, v. 10, n. 2 FEB 2020. Web of Science Citations: 0.
BRANDAO CONSOLO, NARA REGINA; FERRARI, VIVIANE BORBA; MESQUITA, LIGIA GARCIA; GOULART, RODRIGO SILVA; PRADA E SILVA, LUIS FELIPE. Zilpaterol hydrochloride improves beef yield, changes palatability traits, and increases calpain-calpastatin gene expression in Nellore heifers. MEAT SCIENCE, v. 121, p. 375-381, NOV 2016. Web of Science Citations: 5.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.