Analysis of the lincRNA transcriptome in the accessory olfactory system

• Grant number: 16/05379-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2016
• End date: February 28, 2018
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Fabio Papes
• Grantee: Antônio Pedro de Castello Branco da Rocha Camargo
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The olfactory system is a sensory system capable of detecting environmental chemical cues, leading to the sensation of an odor and/or behavioral and endocrine changes. In order to perform these functions, this system comprises two olfactory organs, the main olfactory epithelium and the vomeronasal organ, found in the nasal cavity of mammals. Recently, a huge variety of long non-coding RNA (lncRNAs) has been discovered in several tissues, playing roles in the regulation of gene expression. Given the unique properties of the process by which genes coding for olfactory receptors are expressed in the vomeronasal organ sensory neurons, we hypothesize that lncRNAs might be involved in such regulation. This project aims to identify intergenic long non-coding RNAs (lincRNAs) expressed in the vomeronasal organ of mice, as well as begin their functional characterization in regards to the physiology of olfactory tissues.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMARGO, ANTONIO P.; NAKAHARA, THIAGO S.; FIRMINO, LUIZ E. R.; NETTO, PAULO H. M.; DO NASCIMENTO, JOAO B. P.; DONNARD, ELISA R.; GALANTE, PEDRO A. F.; CARAZZOLLE, MARCELO F.; MALNIC, BETTINA; PAPES, FABIO. Uncovering the mouse olfactory long non-coding transcriptome with a novel machine-learning model. DNA Research, v. 26, n. 4, p. 365-378, AUG 2019. (11/22611-6, 16/24471-0, 18/11860-4, 16/05379-6, 13/08293-7, 15/50371-0)

NAKAHARA, THIAGO; CAMARGO, ANTONIO; FIRMINO, LUIZ; NETTO, PAULO; DO NASCIMENTO, JOAO; DONNARD, ELISA; GALANTE, PEDRO; CARAZZOLLE, MARCELO; MALNIC, BETTINA; PAPES, FABIO. Uncovering long non-coding RNAs in the olfactory sensory organs. CHEMICAL SENSES, v. 45, n. 2, p. 2-pg., 2020-02-01. (16/24471-0, 15/50371-0, 18/11860-4, 11/22611-6, 16/05379-6)

DE CARVALHO, L. M.; BORELLI, G.; CAMARGO, A. P.; DE ASSIS, M. A.; DE FERRAZ, S. M. F.; FIAMENGHI, M. B.; JOSE, J.; MOFATTO, L. S.; NAGAMATSU, S. T.; PERSINOTI, G. F.; et al. Bioinformatics applied to biotechnology: A review towards bioenergy research. BIOMASS & BIOENERGY, v. 123, p. 195-224, APR 2019. (16/05379-6, 16/02792-0, 17/07008-8, 17/13015-7, 13/08293-7, 14/26905-2, 15/06263-9)

NAKAHARA, THIAGO S.; CAMARGO, ANTONIO P.; MAGALHAES, PEDRO H. M.; SOUZA, MATEUS A. A.; RIBEIRO, PEDRO G.; MARTINS-NETTO, PAULO H.; CARVALHO, VINICIUS M. A.; JOSE, JULIANA; PAPES, FABIO. Peripheral oxytocin injection modulates vomeronasal sensory activity and reduces pup-directed aggression in male mice. SCIENTIFIC REPORTS, v. 10, n. 1, NOV 17 2020. (16/05379-6, 15/50371-0, 13/03372-6, 12/21786-0, 16/03641-5, 12/04026-1, 17/01571-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CAMARGO, Antônio Pedro de Castello Branco da Rocha. Analysis of the lincRNA transcriptome in the accessory olfactory system. 2018. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.