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Encapsulation of thymol in nanostructured lipid carriers composed of natural lipids

Grant number: 16/07596-4
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): September 05, 2016
Effective date (End): January 04, 2017
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Priscyla Daniely Marcato Gaspari
Grantee:Thais Priscilla Pivetta
Supervisor: Sandra Isabel Dias Simões
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Universidade de Lisboa, Portugal  
Associated to the scholarship:13/24413-2 - Development of nanostructured lipid carrier of Illipe butter and Calendula oil as a quercetin encapsulation system: physico-chemical and biological evaluation, BP.IC


The wound healing involves the integration of biological and molecular events and in case of chronic wounds can involve the use of drugs that are associated with unwanted side effects. Thus, there is a search by alternatives therapeutics that are less toxic, for example, natural products. The use of natural compounds is an attractive approach to treating inflammatory disorders, wounds and burns. In this context thymol is a promising compound for use in wound healing and inflammatory process due to its properties such as antimicrobial, antioxidant and antiseptic. However essential oils and their constituents, as thymol, exhibit high volatility and can also easily decompose. Thereby the encapsulation of these compounds into nanoparticles is a viable and efficient strategy to modulate the release of the active ingredient to increase the physical stability, decrease its volatility and reduce the toxicity. Thus, the aim of this project is the encapsulation of thymol in nanoparticles composed of natural lipids to increase its penetration into the skin and protect it against degradation. The carrier containing thymol will be produced by emulsion and sonication method and will be evaluated the deformation capacity of the developed nanoparticle. In addition, in vivo studies in mice will be done to investigate the antioxidant and anti-inflammatory activities of the nanoparticles containing thymol. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIVETTA, THAIS P.; SIMOES, SANDRA; ARAUJO, MARGARETE M.; CARVALHO, TANIA; ARRUDA, CAROLINE; MARCATO, PRISCYLA D.. Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 164, p. 281-290, . (13/24413-2, 16/07596-4)
PIVETTA, THAIS P.; SILVA, LETICIA B.; KAWAKAMI, CAMILA M.; ARAUJO, MARGARETE M.; DEL LAMA, MARIA PERPETUA F. M.; NAAL, ROSE MARY Z. G.; MARIA-ENGLER, SILVYA S.; GASPAR, LORENA R.; MARCATO, PRISCYLA D.. Topical formulation of quercetin encapsulated in natural lipid nanocarriers: Evaluation of biological properties and phototoxic effect. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 53, . (16/07596-4, 14/50928-2, 13/24413-2, 08/57805-2)

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