Antioxidant and antiglicante activity of microencapsulation of the extract and saponins obtained from Tribulus terrestris

• Grant number: 15/17893-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2016
• End date: July 31, 2018
• Field of knowledge: Health Sciences - Nutrition - Dietetics
• Principal Investigator: Regildo Márcio Gonçalves da Silva
• Grantee: Célia Cristina Malaguti Figueiredo
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

T. terrestris is widely used in Chinese folk medicine for the treatment of rheumatism, edema, hypertension, kidney stones, astringent, anthelmintic, anti-inflammatory, antispasmodic, anticancer, diuretic, immunomodulatory, diabetes, cardiovascular disorders and for the rejuvenation and physical erectile dysfunction. Therefore this present work aims to develop a controlled release system of steroidal saponins extract and food supplement to base Tribulus terrestris (Androsten®), through microencapsulation technique, with possible application in the food, drug industry and cosmetics. It will be evaluated the antioxidant extract potential, supplement and microcápsulaspor means of in vitro sequestration stable free radical DPPH, ion Fe +3 (FRAP), the nitric oxide radical (NO), lipid peroxidation (TBARS) and method haemolytic. The evaluation of antiglicante activity by the method of protein mobility in electrophoresis and determination of amino grouping will be held. Quantification of phenols, flavonoids and total saponins by means of spectrophotometric techniques and HPLC analysis of the extract supplement and the compounds released from the microcapsules will also be performed.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOMES, AMANDA DA COSTA; ZIBORDI, LAURA CAMARGO; GRANERO, FILIPE OLIVEIRA; XIMENES, VALDECIR FARIAS; PAVAN, NATHALIA MARIANA; SILVA, LUCIANA PEREIRA; SONVESSO, CIBELY DA SILVA MARTIN; JOB, ALDO ELOIZO; NICOLAU, NILSON; SILVA, REGILDO MARCIO GONCALVES DA. Biosynthesis of silver nanoparticles of Tribulus terrestris food supplement and evaluated antioxidant activity and collagenase, elastase and tyrosinase enzyme inhibition: In vitro and in silico approaches. FOOD AND BIOPRODUCTS PROCESSING, v. 138, p. 12-pg., 2023-02-09. (15/17893-3)

MALAGUTI FIGUEIREDO, CELIA CRISTINA; GOMES, AMANDA DA COSTA; GRANERO, FILIPE OLIVEIRA; BRONZEL JUNIOR, JOAO LUIZ; SILVA, LUCIANA PEREIRA; XIMENES, VALDECIR FARIAS; GONCALVES DA SILVA, REGILDO MARCIO. Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release. JOURNAL OF INTEGRATIVE MEDICINE-JIM, v. 20, n. 2, p. 10-pg., 2022-03-01. (15/17893-3)

MALAGUTI FIGUEIREDO, CELIA CRISTINA; GOMES, AMANDA COSTA; GRANERO, FILIPE OLIVEIRA; BRONZEL JUNIOR, JOAO LUIZ; SILVA, LUCIANA PEREIRA; TASCA GOIS RUIZ, ANA LUCIA; GONCALVES DA SILVA, REGILDO MARCIO. Antiglycation and antitumoral activity of Tribulus terrestris dry extract. AVICENNA JOURNAL OF PHYTOMEDICINE, v. 11, n. 3, p. 224-237, MAY-JUN 2021. (15/17893-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FIGUEIREDO, Célia Cristina Malaguti. Antioxidant activity, antigliding and microencapsulation of saponins obtained from Tribulus terrestris. 2018. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.