Anticaries effect of fluoride toothpaste and supplemented with sodium trimetaphosphate nano-sizeds on enamel demineralization and biofilm: an in situ study

• Grant number: 16/12581-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2016
• End date: July 31, 2017
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Marcelle Danelon
• Grantee: Gabriel Pereira Nunes
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The decline in dental caries in the last two decades has been attributed to the widespread use of fluorides. Some of the presentations are fluoridated toothpastes, of great use by the population. The present project proposal is to evaluate, in situ, the ability of fluoridated toothpastes and supplemented with sodium trimetaphosphate nanoparticulate (TMPnano), to reduce the demineralization of enamel and its effect on biofilms. bovine blocks (n = 192) will be selected through the initial surface hardness (SHI) and then twelve volunteers (n = 12) use palatal appliances containing 4 enamel blocks for 7 days in 4 experimental phases: 1) Dentifrice without F/TMP/TMPnano (Placebo); 2) Toothpaste F 1100 ppm (F); 3) 1100 ppm F dentifrice associated with 3% TMP microparticle (F + TMP) and 4) toothpaste 1100 ppm associated with 3% TMPnano (F + TMPnano). The cariogenic challenge will be produced by using a sucrose 30% solution. After the trial is performed to analyze the fluoride content (F), calcium (Ca) and phosphorus (P) and alkali-soluble carbohydrates. In enamel blocks will be determined the hardness of the end surface (SHF) for calculating the surface hardness loss percentage (% SH). the most appropriate statistical test to the distribution of the data will be used by the statistical program Sigmaplot © software for Windows version 12.0, with a significance of 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

EMERENCIANO, NAYARA GONSALVES; BOTAZZO DELBEM, ALBERTO CARLOS; PESSAN, JULIANO PELIM; NUNES, GABRIEL PEREIRA; SOUZA NETO, FRANCISCO NUNES; DE CAMARGO, EMERSON RODRIGUES; DANELON, MARCELLE. In situ effect of fluoride toothpaste supplemented with nano-sized sodium trimetaphosphate on enamel demineralization prevention and biofilm composition. ARCHIVES OF ORAL BIOLOGY, v. 96, p. 223-229, DEC 2018. (16/12581-6)