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Metagenomic and immune-inflammatory analysis of individuals with generalized aggressive periodontitis and their descendants

Grant number: 16/03704-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2016
Effective date (End): February 28, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Renato Corrêa Viana Casarin
Grantee:Mabelle de Freitas Monteiro
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated scholarship(s):16/19970-8 - Metagenomic and immune-inflammatory analysis of individuals with generalized aggressive periodontitis and their descendants, BE.EP.DR

Abstract

Generalized aggressive periodontitis is a multifactorial disease related to several aspects that influence it installation and progression. A constant microbial colonization, an altered inflammatory response and a clear genetic factor are cited as possible factors associated to this pathology. Thus, aggressive periodontitis subjects could transmit for their descendants some genetical alterations, such as inflammatory response pattern associated to periodontal destruction and susceptibility to colonization by some pathogens, increasing the risk of develops this disease. This way, this project is aimed to evaluate the pattern of microbiological colonization and the inflammatory response pattern associated to it, comparing parents with generalized aggressive periodontitis and their children and periodontally healthy parents and their children. Thirty families will be selected and divided in two groups: Test group (n=15 families) families in which the parents (or at least one of them) present generalized aggressive periodontitis and one child (age ranging from 6-12 years old); Control group (n=15 families) families in which the parents (both of them) present periodontal healthy and one child (age ranging from 6-12 years old). The groups will be composed using a gender- and age-matched structure. The children will participate of a hygiene program and will be monitored for 3 months. All individuals (parents and children) will be clinically assessed for plaque and bleeding index, periodontal probing depth, clinical attachment level and gingival recession. During this period, samples of gingival crevicular fluid (GCF) and subgingival biofilm from periodontal pockets/sites from all subject (parents and children) will be collected. The GCF will be analyzed and the detection of IL-1², IL-4, IL-6, IL-8, IL-10, IL-17, TNF-a and INF-g will be done using Luminex/MAGpix technology. In subgingival biofilm the DNA will be extracted and the microbiome and its functional characteristics will be evaluated by metagenomics and bioinformatics analysis. The data will be compared by Student's t test, Mann-Whitney e Wilcoxon tests. The significance level for all analysis will be 5%.

News published in Agência FAPESP Newsletter about the scholarship:
Bactérias que provocam periodontite são transmitidas de pais para filhos 
Las bacterias que provocan la periodontitis se transmiten de padres a hijos 
Bacteria that cause periodontitis are transmitted from parents to children 
Articles published in other media outlets (62 total):
More itemsLess items
UOL: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Al Día (Cuba): Las bacterias que provocan la periodontitis se transmiten de padres a hijos (11/May/2021)
Blog Dental News Report: Bacteria that cause periodontitis are transmitted from parents to children (11/May/2021)
Mundo Deportivo (Espanha) online: ¿La periodontitis se hereda de padres a hijos? (20/Apr/2021)
Cybermark Solutions: Bacteria that cause periodontitis are transmitted from parents to children (20/Apr/2021)
Globedia (Colômbia): La periodontitis, ¿se 'hereda' de padres a hijos? (19/Apr/2021)
El Medico Interactivo (Espanha): Las bacterias que causan periodontitis se transmiten de padres a hijos (19/Apr/2021)
Diario de Salud (República Dominicana): La periodontitis, ¿se 'hereda' de padres a hijos? (19/Apr/2021)
iSanidad (Espanha): Investigadores observan que las bacterias que causan periodontitis se transmiten de padres a hijos (19/Apr/2021)
Infosalus (Espanha): La periodontitis, ¿se 'hereda' de padres a hijos? (18/Apr/2021)
Crônica Balear (Espanha): Investigadores observan que las bacterias que causan periodontitis se transmiten de padres a hijos (18/Apr/2021)
El Mira (Espanha): ¿Qué es la periodontitis? Estudios confirman que podría pasar de padres a hijos (18/Apr/2021)
Science Mission (EUA): Bacteria that cause periodontitis are transmitted from parents to children (17/Apr/2021)
Dentistry: Adults with gum disease can transmit the bacteria to children (16/Apr/2021)
News Medical (Austrália): Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
Medical Xpress (Reino Unido): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
InfoSurHoy (EUA): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Health Problems News: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
HealthCareaccountServices: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
SOHU.com (China): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
INS - Infusion Nurses Society (EUA): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Medical Dialogues (Índia): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Xw.qq.com (China): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Nsane.forums: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Medical Life Sciences: Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
Oullins-Patriote.com: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Medical Advise (EUA): Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
LaptrinhX: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
MediExpose (ìndia): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Wees: Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
Quicknews (África do Sul): Parents can Transmit Periodontitis-causing Bacteria to Children (15/Apr/2021)
Nsane.forums: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Baby Daily News (EUA): Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
LinkNet-News: Micro organism that trigger periodontitis are transmitted from dad and mom to youngsters (15/Apr/2021)
Odontologia33 (Espanha): Las bacterias que causan periodontitis se transmiten de padres a hijos (15/Apr/2021)
Perioimplantlaser.com (Irã): باکتریهایی که باعث پریودنتیت می شوند از والدین به فرزندان منتقل می گردند (15/Apr/2021)
Dental Nursing (Reino Unido): Children' inherit' perio problems from parents (15/Apr/2021)
Awebfind.biz: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Bioengineer (Reino Unido): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Science Codex: Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Scienmag Science Magazine (Reino Unido): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Biotech Asia News (Índia): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
4State News: Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Clinical Research News: Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
WebNewsTime (Austrália): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
The Uncover Reality (Índia): Bacteria that cause periodontitis are transmitted from parents to children (11/Apr/2021)
Plantão News (MT): Bactérias que provocam periodontite são transmitidas de pais para filhos (28/Mar/2021)
MSN: Bactérias que provocam periodontite são transmitidas de pais para filhos (25/Mar/2021)
eCycle: Bactérias que provocam periodontite são transmitidas de pais para filhos (24/Mar/2021)
Diário Potiguar: Bactérias que provocam periodontite são transmitidas de pais para filhos (21/Mar/2021)
Bem Pra Você Oficial: Bactérias que provocam periodontite são transmitidas de pais para filhos (21/Mar/2021)
Espaço Ecológico no Ar: Bactérias que provocam periodontite são transmitidas de pais para filhos (20/Mar/2021)
Diário da Saúde: Pais transmitem bactérias da periodontite para os filhos (19/Mar/2021)
Saense: Bactérias que provocam periodontite são transmitidas de pais para filhos (19/Mar/2021)
Leiamais.ba: Bactérias que atacam gengivas são transmitidas dos pais para os filhos (19/Mar/2021)
Casa de Notícias: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Blog Jornal da Mulher: Bactérias que provocam periodontite são transmitidas de pais para filho (18/Mar/2021)
Revista Pará: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Portal da Enfermagem: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
InfoHealth: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Gazeta de Alagoas online: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Quimiweb: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO, MABELLE FREITAS; ALTABTBAEI, KHALED; KUMAR, PURNIMA S.; CASATI, MARCIO ZAFFALON; SILVERIO RUIZ, KARINA GONZALES; SALLUM, ENILSON ANTONIO; NOCITI-JUNIOR, FRANCISCO HUMBERTO; VIANA CASARIN, RENATO CORREA. Parents with periodontitis impact the subgingival colonization of their offspring. SCIENTIFIC REPORTS, v. 11, n. 1 JAN 14 2021. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.