Metagenomic and proteomic analysis of individuals with generalized aggressive periodontitis and their descendants

• Grant number: 15/50264-0
• Support Opportunities: Regular Research Grants
• Duration: April 01, 2016 - March 31, 2018
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Convênio/Acordo: Ohio State University
• Principal Investigator: Renato Corrêa Viana Casarin
• Grantee: Renato Corrêa Viana Casarin
• Principal researcher abroad: Purnima Kumar
• Institution abroad: Ohio State University, Columbus, United States
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Generalized aggressive periodontitis (GAgP) is a disease that destroys the tissues that anchor the tooth to the jawbone in young and systemically healthy subjects (Armitage, 1999). This devastating disease occurs due a florid host response to a dysbiotic oral microbial community and results in tooth loss at a very young age, with resulting complications of poor nutritional status, and loss of speech and masticatory function. The complexity of its pathogenesis and clinical severity has drawn the attention of clinicians and researchers for several decades. Although intensely studied, the lack of information about the affected population, etiology, initiation and progression of disease is a serious impediment to a complete comprehension of disease process and to determine more robust diagnostic criteria, preventive approaches and more predictable clinical intervention. Interestingly, GAgP presents a clear and consistent familial aggregation, making the children from affected subjects a high-risk population, although, up to date, no study has comprehensively studied these children. So, in order to improve knowledge regarding GAgP disease and also determine future risk factors for GAgP development, we propose studies that combine a prospective, interventional, case-control clinical study, high-throughput molecular microbiological and immunological approaches to elucidate the etiological patterns of aggressive periodontitis. Completion of these studies will (I) provide us with data on the familial nature of the disease, and (II) identify factors that are heritable versus those that are environmentally acquired. Such a study has never been done before, and has the potential to change the current paradigms of disease etiology and therefore, create a major impact on treatment of the disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MONTEIRO, MABELLE FREITAS; ALTABTBAEI, KHALED; KUMAR, PURNIMA S.; CASATI, MARCIO ZAFFALON; SILVERIO RUIZ, KARINA GONZALES; SALLUM, ENILSON ANTONIO; NOCITI-JUNIOR, FRANCISCO HUMBERTO; VIANA CASARIN, RENATO CORREA. Parents with periodontitis impact the subgingival colonization of their offspring. SCIENTIFIC REPORTS, v. 11, n. 1, JAN 14 2021. (15/50264-0, 16/03704-7, 16/19970-8)