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Metagenomic and immune-inflammatory analysis of individuals with generalized aggressive periodontitis and their descendants

Grant number: 16/19970-8
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): April 01, 2017
Effective date (End): March 31, 2018
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Renato Corrêa Viana Casarin
Grantee:Mabelle de Freitas Monteiro
Supervisor abroad: Purnima Kumar
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Research place: Ohio State University, Columbus, United States  
Associated to the scholarship:16/03704-7 - Metagenomic and immune-inflammatory analysis of individuals with generalized aggressive periodontitis and their descendants, BP.DR

Abstract

Generalized aggressive periodontitis (GAgP) is a multifactorial disease related to several aspects that influence it installation and progression. The familiar aggregation, an altered inflammatory pattern and the microbial etiology are important characteristic of this disease and could be associated to susceptibility to aggressive periodontitis. Thus, aggressive periodontitis subjects could transmit for their descendants some characteristics, such as susceptibility for colonization and some periodontopathogens, which could influence the development of GAgP. In this vein, the aim of this project is to evaluate the pattern of microbiological colonization as such as the influence of this microbial colonization in the subgingival environment in subjects with GAgP and their children, comparing to periodontally healthy subjects and their children. Thirty families will be selected and divided in two groups: Test group (n=15 families) families in which the parents (or at least one of them) present generalized aggressive periodontitis and one child (age ranging from 6-12 years old); Control group (n=15 families) families in which the parents (both of them) present periodontal healthy and one child (age ranging from 6-12 years old). The groups will be composed using a gender- and age-matched structure. The subgingival biofilm will be collected from first molars and incisors of parents and children and it will be evaluated using a high-throughput technology for microbiological deep sequencing metagenomics analysis. The DNA of biofilm will be extracted and the microbiome and its functional characteristics will be evaluated by metagenomics and bioinformatics analysis. The microbiological data generate in OSU will be evaluated together with the clinical and inflammatory data generate in Brazil. The data will be compared by Chi-square, Student's t test, Mann-Whitney e Wilcoxon tests. The significance level for all analysis will be 5%.

News published in Agência FAPESP Newsletter about the scholarship:
Bactérias que provocam periodontite são transmitidas de pais para filhos 
Las bacterias que provocan la periodontitis se transmiten de padres a hijos 
Bacteria that cause periodontitis are transmitted from parents to children 
Articles published in other media outlets (62 total):
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UOL: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Al Día (Cuba): Las bacterias que provocan la periodontitis se transmiten de padres a hijos (11/May/2021)
Blog Dental News Report: Bacteria that cause periodontitis are transmitted from parents to children (11/May/2021)
Mundo Deportivo (Espanha) online: ¿La periodontitis se hereda de padres a hijos? (20/Apr/2021)
Cybermark Solutions: Bacteria that cause periodontitis are transmitted from parents to children (20/Apr/2021)
Globedia (Colômbia): La periodontitis, ¿se 'hereda' de padres a hijos? (19/Apr/2021)
El Medico Interactivo (Espanha): Las bacterias que causan periodontitis se transmiten de padres a hijos (19/Apr/2021)
Diario de Salud (República Dominicana): La periodontitis, ¿se 'hereda' de padres a hijos? (19/Apr/2021)
iSanidad (Espanha): Investigadores observan que las bacterias que causan periodontitis se transmiten de padres a hijos (19/Apr/2021)
Infosalus (Espanha): La periodontitis, ¿se 'hereda' de padres a hijos? (18/Apr/2021)
Crônica Balear (Espanha): Investigadores observan que las bacterias que causan periodontitis se transmiten de padres a hijos (18/Apr/2021)
El Mira (Espanha): ¿Qué es la periodontitis? Estudios confirman que podría pasar de padres a hijos (18/Apr/2021)
Science Mission (EUA): Bacteria that cause periodontitis are transmitted from parents to children (17/Apr/2021)
Dentistry: Adults with gum disease can transmit the bacteria to children (16/Apr/2021)
News Medical (Austrália): Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
Medical Xpress (Reino Unido): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
InfoSurHoy (EUA): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Health Problems News: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
HealthCareaccountServices: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
SOHU.com (China): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
INS - Infusion Nurses Society (EUA): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Medical Dialogues (Índia): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Xw.qq.com (China): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Nsane.forums: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Medical Life Sciences: Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
Oullins-Patriote.com: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Medical Advise (EUA): Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
LaptrinhX: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
MediExpose (ìndia): Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Wees: Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
Quicknews (África do Sul): Parents can Transmit Periodontitis-causing Bacteria to Children (15/Apr/2021)
Nsane.forums: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Baby Daily News (EUA): Adults with periodontitis transmit bacteria that can later cause the disease in their children (15/Apr/2021)
LinkNet-News: Micro organism that trigger periodontitis are transmitted from dad and mom to youngsters (15/Apr/2021)
Odontologia33 (Espanha): Las bacterias que causan periodontitis se transmiten de padres a hijos (15/Apr/2021)
Perioimplantlaser.com (Irã): باکتریهایی که باعث پریودنتیت می شوند از والدین به فرزندان منتقل می گردند (15/Apr/2021)
Dental Nursing (Reino Unido): Children' inherit' perio problems from parents (15/Apr/2021)
Awebfind.biz: Bacteria that cause periodontitis are transmitted from parents to children (15/Apr/2021)
Bioengineer (Reino Unido): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Science Codex: Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Scienmag Science Magazine (Reino Unido): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Biotech Asia News (Índia): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
4State News: Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
Clinical Research News: Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
WebNewsTime (Austrália): Bacteria that cause periodontitis are transmitted from parents to children (14/Apr/2021)
The Uncover Reality (Índia): Bacteria that cause periodontitis are transmitted from parents to children (11/Apr/2021)
Plantão News (MT): Bactérias que provocam periodontite são transmitidas de pais para filhos (28/Mar/2021)
MSN: Bactérias que provocam periodontite são transmitidas de pais para filhos (25/Mar/2021)
eCycle: Bactérias que provocam periodontite são transmitidas de pais para filhos (24/Mar/2021)
Diário Potiguar: Bactérias que provocam periodontite são transmitidas de pais para filhos (21/Mar/2021)
Bem Pra Você Oficial: Bactérias que provocam periodontite são transmitidas de pais para filhos (21/Mar/2021)
Espaço Ecológico no Ar: Bactérias que provocam periodontite são transmitidas de pais para filhos (20/Mar/2021)
Diário da Saúde: Pais transmitem bactérias da periodontite para os filhos (19/Mar/2021)
Saense: Bactérias que provocam periodontite são transmitidas de pais para filhos (19/Mar/2021)
Leiamais.ba: Bactérias que atacam gengivas são transmitidas dos pais para os filhos (19/Mar/2021)
Casa de Notícias: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Blog Jornal da Mulher: Bactérias que provocam periodontite são transmitidas de pais para filho (18/Mar/2021)
Revista Pará: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Portal da Enfermagem: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
InfoHealth: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Gazeta de Alagoas online: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)
Quimiweb: Bactérias que provocam periodontite são transmitidas de pais para filhos (18/Mar/2021)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO, MABELLE FREITAS; ALTABTBAEI, KHALED; KUMAR, PURNIMA S.; CASATI, MARCIO ZAFFALON; SILVERIO RUIZ, KARINA GONZALES; SALLUM, ENILSON ANTONIO; NOCITI-JUNIOR, FRANCISCO HUMBERTO; VIANA CASARIN, RENATO CORREA. Parents with periodontitis impact the subgingival colonization of their offspring. SCIENTIFIC REPORTS, v. 11, n. 1 JAN 14 2021. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.