Hybrid complexes of polyelectrolytes and magnetite for control release of amoxycillin

• Grant number: 16/08750-7
• Support type: Scholarships in Brazil - Master
• Effective date (Start): October 01, 2016
• Effective date (End): February 28, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Denise Freitas Siqueira Petri
• Grantee: Pedro Vinicius de Assis Bueno
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Novel biocompatible systems for biotechnological applications are important not only from the technological point of view, but also for scientific advances. The present proposal aims to the creation and characterization of thin (thickness smaller than 100 nm) or micrometric (thickness ranging from 50 ¼m to 100 ¼m) films composed of xanthan gum (GXT) and poly(diallyldimethylammonium chloride)or polylysine, in the absence and in the presence of magnetic nanoparticles (NPM). The incorporation of amoxicillin (AMOX), an antibiotic widely used against many infections, in the hydrogels and films will be carried out during the systems formation. The release kinetics will investigated as a function of pH and external magnetic field of 0.4 T and will be evaluated by means of Kosmeyer-Peppas model. The best conditions will chose for the development of transdermal patches for control release of AMOX.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUENO, PEDRO V. A.; HILAMATU, KARINA C. P.; CARMONA-RIBEIRO, ANA M.; PETRI, DENISE F. S. Magnetically triggered release of amoxicillin from xanthan/Fe3O4/albumin patches. International Journal of Biological Macromolecules, v. 115, p. 792-800, AUG 2018. Web of Science Citations: 2.