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Neuropsychological assessment of children and adolescents with OCD:comparison with healthy controls and impact of treatment

Grant number: 16/04595-7
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2016
Effective date (End): March 31, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Roseli Gedanke Shavitt
Grantee:Marina de Marco e Souza
Home Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Introduction: The literature on neuropsychological profile of children and adolescents with obsessive-compulsive disorder (OCD) is still quite scarce and inconsistent when it comes to data on the possible cognitive impairment in this population. The aforementioned deterioration relates to fronto-striatal circuitry, especially with regard to executive functions and nonverbal memory. Objectives: To assess possible changes in cognitive functioning of children and adolescents with OCD and associations between neuropsychological measures, clinical data and response to pharmacological and psychotherapeutic treatments. Methods: 86 patients with OCD and 86 healthy controls, aged between 6 and 17 years, will be evaluated by scales and questionnaires to assess psychiatric symptoms and by a battery of neuropsychological tests. All subjects will undergo such assessments at an early time, while patients after being randomized between two possibilities of treatment, cognitive-behavioral group therapy or fluoxetine, will undergo two new assessments: at the 14th and then at the 28th weeks of treatment. Assumptions: 1) patients will present impairments in tasks that assess planning, mental flexibility, inhibitory control and non-verbal episodic memory when compared with healthy controls; 2) the treatments will have a positive influence in the improvement of cognitive functions of patients, especially those that are compromised compared to controls; 3) clinical improvement will correlate positively with improved neuropsychological performance of patients.