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ASSESMENT OF THE ANTI-INFLAMMATORY EFFECTS OF ENDURANCE TRAINING IN ADIPOSE TISSUE: THE POSSIBLE MEDIATING ROLE OF ADIPONECTIN

Grant number: 16/02696-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2017
Effective date (End): April 08, 2021
Field of knowledge:Health Sciences - Physical Education
Principal researcher:José Cesar Rosa Neto
Grantee:Tiego Aparecido Diniz
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):19/10530-3 - The role of CaMKK2 in the exercise-mediated mental health benefits, BE.EP.DR

Abstract

Obesity is considered one of the major causes of mortality and morbidity worldwide, as well as, a public health concern. Nowadays, adipose tissue is considered an endocrine organ due its ability to produce cytokines, such as interleukins (IL), tumor necrosis factor-± (TNF-±), adiponectin, among others. Epidemiological studies have been shown that increased adipose tissue can augment the production of pro-inflammatory cytokines (low-grade chronic inflammation [LGCI]), which are associated with several comorbidities. Therefore, since aerobic exercise can decrease LGCI, this exercise has been reported as a great way to treatment this outcome. Another plausible hypothesis is that aerobic training can increase, both acute and chronic, the levels of adiponectin. Adiponectin, produced mainly by subcutaneous adipose tissue, has been widely studied regarding its anti-inflammatory effects, as the suppression of Toll-like receptor (TLR-4) pathway, which reduces the production of pro-inflammatory cytokines (interferon-³, IL-6, IL-1² e TNF-±). Moreover, adiponectina can augment the expression of anti-inflammatory cytokines such as IL-10 and IL-1ra via another pathway. These effects were observed in immune cells and adipocytes, showing this adipokine can be involved in the anti-inflammatory effects of aerobic training. Given that aerobic exercise can increase adiponectin concentrations and this one exerts an anti-inflammatory role in adipose tissue, the aim of the present study will be investigate if the anti-inflammatory effects of aerobic exercise in adipose tissue occur in an adiponectin-mediated pathway.We will use C57BL/6 and adiponectin knockout (Adiponectin-/- [AdipoKO]) mice aged 4 to 6 week. Firstly, we will analyze what exercise intensity (60% and 85% VO2max) is better to promote anti-inflammatory effects in adipose tissue. After, both types of animals will be divided into the following groups: 1) control (balanced diet); 2) high fat diet (HFD) and; 3) HFD plus aerobic training (12 weeks). At this moment, we will evaluate in the plasma and adipose tissue the metabolic and inflammatory profile before and after interventions. If adiponectin is required for the anti-inflammatory effects of exercise, we will transplant the subcutaneous adipose tissue of C57B/6 to AdipoKO aiming to verify whether the disorders caused by the absence of adiponectin are reversed.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DINIZ, TIEGO APARECIDO; DE LIMA JUNIOR, EDSON ALVES; TEIXEIRA, ALEXANDRE ABILIO; BIONDO, LUANA AMORIM; FERNANDES ROCHA, LUCAS ARIEL; VALADAO, IURI CORDEIRO; SILVEIRA, LOREANA SANCHES; CABRAL-SANTOS, CAROL; DE SOUZA, CAMILA OLIVEIRA; ROSA NETO, JOSE CESAR. Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-alpha signaling in obese mice. Life Sciences, v. 266, FEB 1 2021. Web of Science Citations: 0.
DINIZ, TIEGO A.; JONCO AQUINO JUNIOR, JEFFERSON COMIN; MOSELE, FRANCIELLE CAROLINE; CABRAL-SANTOS, CAROLINA; DE LIMA JUNIOR, EDSON ALVES; DE SOUZA TEIXEIRA, ALEXANDRE ABILIO; LIRA, FABIO SANTOS; ROSA NETO, JOSE CESAR. Exercise-induced AMPK activation and IL-6 muscle production are disturbed in adiponectin knockout mice. CYTOKINE, v. 119, p. 71-80, JUL 2019. Web of Science Citations: 2.

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