| Grant number: | 16/16641-3 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | January 01, 2017 |
| End date: | February 28, 2018 |
| Field of knowledge: | Health Sciences - Pharmacy - Pharmaceutical Technology |
| Agreement: | Coordination of Improvement of Higher Education Personnel (CAPES) |
| Principal Investigator: | Vitor Manuel Cardoso Figueiredo Balcão |
| Grantee: | Liliam Katsue Harada Rocha |
| Host Institution: | Pró-Reitoria Acadêmica. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil |
Abstract Hydrogels are structures formed by three-dimensional network of crosslinked hydrophilic polymers. The biopolymeric hydrogels are very interesting for use in skin regeneration and treatment of skin wounds, such as bandages, due to many factors, including low toxicity. In preparing hydrogels are used both natural and synthetic polymers, polymerized by different processes. In this research project, provides for the use of biopolysaccharide xanthan and carrageenan gum. The sericin will be incorporate in biohydrogels as active. Sericin is a bioactive globular protein which composes 25-30% of the silk proteins. Due to their unique biochemical and biophysical properties it has been studied for many potential applications. The main objective of this work is to develop and evaluate a biopolymeric hydrogel, integrating sericin with skin regeneration potential. The sericin , extracted from silkworm cocoon (Bombyx mori), will be compared to sericin standard and characterized extensively. Following the characterization of sericin, will be produced and will be optimize biopolymeric hydrogel for functional and structural stabilization of sericin, using full factorial design 32 (2 variables (% (w/w)xanthan gum and % (w/w)carrageenan) at 3 levels ((-1), (0) and (+1)) with the addition of PVA (98% hydrolysed) to 1.25% (w/v) polymerizer, and glycerol to 2.5%(w/v) to induce plasticizing effect, thereby yielding 09 formulations. For the statistically optimized hydrogel, sericin incorporation will be in concentrations of 0, 1, 2, 5, 10, 20 and 50 mgsericina / mLhydrogel. The obtained formulations will be evaluated considering the ability to release the sericin, and characterization tests both physical-chemical and biological. (AU) | |
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