| Grant number: | 17/02915-7 |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |
| Start date: | March 31, 2017 |
| End date: | May 30, 2017 |
| Field of knowledge: | Agronomical Sciences - Animal Husbandry - Animal Production |
| Principal Investigator: | Débora Botéquio Moretti |
| Grantee: | Mariana Caroline Furian Pontin |
| Supervisor: | Ouliana Ziouzenkova |
| Host Institution: | Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil |
| Institution abroad: | Ohio State University, Columbus, United States |
| Associated to the scholarship: | 15/16151-3 - Antioxidant protection of bovine colostrum on intestinal cells of juvenile pacu (Piaractus mesopotamicus) undergoing stress, BP.MS |
Abstract Colostrum has important biological molecules, such as immunoglobulin, that aid the newborn to overcome challenges in the first weeks of life. Growth factors are known to increase the proliferation and intestinal cell differentiation and the antimicrobial factors are responsible for inhibiting the bacterial activity and growth. The antioxidants components of colostrum prevent oxidative cell damage caused by free radicals thereby protecting and improving the calf's development. Immunoglobulins, lactoferrin, lactoperoxidase, lysozyme, and antioxidants confers antibacterial and anti-inflammatory properties of colostrum, since oxidative stress and microbial infections play a major role in inflammation-induced diseases. Colostrum composition varied between animals, and depend on nutrition and other environmental factors. Here we propose to develop an assay for cumulative assessment of colostrum properties as antioxidant, anti-inflammatory agent and energy source. We will develop this assay using biosensor cell lines that were previously developed in the hosting Dr. Ziouzenkova's laboratory. These cells are stably transfected with gene constructs that "report" anti-inflammatory, anti-oxidative, and anti-obesogenic properties of diverse classes of compounds from foods. Various concentrations of colostrum will be tested and compared with known agonists and antagonists of such reporter activities. These in vitro assay will provide cumulative assessment for colostrum biomedical properties. We will also utilize nanoscaffold to improve colostrum absorption. The successful execution of this project will provide a new means of testing biomedical quality of natural foods in diverse environments. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |