Development and application of calcium phosphate nanoparticles functionalized with acidic monomers for dental remineralization

• Grant number: 16/25971-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2017
• End date: March 31, 2019
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Roberto Ruggiero Braga
• Grantee: Marina Damasceno e Souza de Carvalho Chiari
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 18/02403-9 - Effect on bond strength and collagen degradation of experimental dentin adhesives containing calcium orthophosphate particles, BE.EP.MS

Abstract

Calcium phosphate nanoparticles functionalization with ethylene glycol dimethacrylate derivatives is proved to be effective in reducing the negative effects of addition of calcium phosphate nanoparticles over the mechanical properties of resin composites. However, there were no significant reductions in the nanoparticle agglomeration. This project aims to: 1) investigate the effect of functionalization with different organic agents on the characteristics of CaP nanoparticles; 2) evaluate experimental composites containing these particles in relation to mechanical properties, degree of conversion, release of Ca2 + ions and HPO42- and their protective effect, in vitro, on the enamel adjacent to restorations in specimens submitted to a acid challenge. Data will be subjected to either one-way ANOVA (degree of conversion, mechanical properties and microhardness after acidic challenge) or two-way ANOVA (ion release). In all cases, Tukey test will be used for pair-wise comparisons. The global significance level (±) will be set at 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHIARI, MARINA D. S.; ALANIA, YVETTE; BEDRAN-RUSSO, ANA K.; BRAGA, ROBERTO R.. Experimental dentin adhesives containing calcium orthophosphate particles: Effect on dentin bond strength, micro-permeability and collagen degradation. INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, v. 107, JUN 2021. (16/25971-7, 18/02403-9)

VILELA, HANDIALLY S.; CAMPOS, AMANDA L.; CABRAL, CAMILA; CHIARI, MARINA D. S.; VIEIRA, DOUGLAS N.; BRAGA, ROBERTO R.. Effect of calcium orthophosphate: Reinforcing glass ratio and prolonged water storage on flexural properties of remineralizing composites. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 104, APR 2020. (16/25971-7)

CHIARI, MARINA D. S.; RODRIGUES, MARCELA C.; PINTO, MIRELLA F. C.; VIEIRA, DOUGLAS N.; VICHI, FLAVIO M.; VEGA, OSCAR; CHRZANOWSKI, WOJCIECH; NAGAOKA, NORIYUKI; BRAGA, ROBERTO R.. Development of brushite particles synthesized in the presence of acidic monomers for dental applications. Materials Science & Engineering C-Materials for Biological Applications, v. 116, NOV 2020. (17/06446-1, 16/50321-6, 16/25971-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CHIARI, Marina Damasceno e Souza de Carvalho. Development and application of calcium phosphate particles functionalized with acidic monomers for dental remineralization. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.