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Development of a bioactive and antibacterial surface containing Cu2O for dental implants

Grant number: 17/01320-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2017
Effective date (End): April 30, 2021
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Valentim Adelino Ricardo Barão
Grantee:Jairo Matozinho Cordeiro
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated scholarship(s):19/07956-9 - Biological response of biomaterials loaded with copper ions for dental implants rehabilitation, BE.EP.DR


The search for dental implants surfaces that prevent infections and improve the biological properties is still a challenging. This study aims to develop bioactive and antibacterial surfaces containing cooper oxide (Cu2O) onto commercially pure titanium (cpTi) discs by means of plasma electrolytic oxidation (PEO). CpTi discs (15 mm diameter and 2 mm thickness) will be subjected to different surface modifications: machined (surface I - control); modified by PEO with calcium and phosphate solution (surface II); modified by PEO with solution of calcium, phosphate and Cu2O nanoparticles (surface III). The surfaces will be characterized as surface roughness (Ra, Rq, Rt, Rz), atomic force microscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction analysis (XRD), X-ray photoelectron spectroscopy, wettability and surface free energy. For the electrochemical assay, standard tests (open circuit potential, electrochemical impedance spectroscopy, and potentiodynamic tests) will be conducted in body fluid solution (pH 7,4) to understand the corrosion kinetics and to investigate the properties of the oxide film formed on the discs surface. For biological tests, murine osteoprogenitor cell line (MC3T3E1) will be used. The cell structure and morphology will be evaluated by SEM. The quantitative reverse transcription polymerase chain reaction (qRT-PCR) will be used to check the levels of osteogenic genes expression. MTT assay will be used to assess cell viability. The influence of surface treatment on the adsorption of serum proteins (albumin, fibrinogen and fibronectin) will be determined by the bicinchoninic acidic method. For microbiological test, the biofilm composed of Streptococcus sanguinis will be formed onto the discs surfaces. The log of colony forming units will be determined (log CFU), and the biofilm structure will be analyzed by SEM. Quantitative data will be submitted to the most appropriate statistical analysis with 5% significance level. The number of specimens for each test will be determined after the pilot study. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VAN OIRSCHOT, BART A. J. A.; ZHANG, YANG; ALGHAMDI, HAMDAN S.; CORDEIRO, JAIRO M.; NAGAY, BRUNA E.; BARAO, VALENTIM A. R.; DE AVILA, ERICA DORIGATTI; VAN DEN BEUCKEN, JEROEN J. J. P.. Surface Engineering for Dental Implantology: Favoring Tissue Responses Along the Implant. TISSUE ENGINEERING PART A, v. 28, n. 11-12, p. 18-pg., . (20/05231-4, 18/20719-3, 21/09434-0, 19/17238-6, 17/01320-0, 15/03567-7)
CORDEIRO, JAIRO M.; PANTAROTO, HELOISA N.; PASCHOALETO, EMANUELLA M.; RANGEL, ELIDIANE C.; DA CRUZ, NILSON C.; SUKOTJO, CORTINO; BARAO, VALENTIM A. R.. Synthesis of biofunctional coating for a TiZr alloy: Surface, electrochemical, and biological characterizations. Applied Surface Science, v. 452, p. 268-278, . (17/01320-0, 16/11470-6)
CORDEIRO, JAIRO M.; NAGAY, BRUNA E.; RIBEIRO, ANA LUCIA R.; DA CRUZ, NILSON C.; RANGEL, ELIDIANE C.; FAIS, LAIZA M. G.; VAZ, LUIS G.; BARAO, VALENTIM A. R.. Functionalization of an experimental Ti-Nb-Zr-Ta alloy with a biomimetic coating produced by plasma electrolytic oxidation. Journal of Alloys and Compounds, v. 770, p. 1038-1048, . (17/01320-0, 16/11470-6)
NAGAY, BRUNA E.; DINI, CAROLINE; CORDEIRO, JAIRO M.; RICOMINI-FILHO, ANTONIO P.; DE AVILA, ERICA D.; RANGEL, ELIDIANE C.; DA CRUZ, NILSON C.; BARAO, VALENTIM A. R.. Visible-Light-Induced Photocatalytic and Antibacterial Activity of TiO2 Codoped with Nitrogen and Bismuth: New Perspectives to Control Implant-Biofilm-Related Diseases. ACS APPLIED MATERIALS & INTERFACES, v. 11, n. 20, p. 18186-18202, . (16/11470-6, 17/01320-0, 17/00314-6)
CORDEIRO, JAIRO M.; PIRES, JULIA M.; SOUZA, JOAO G. S.; LIMA, CAROLINA V.; BERTOLINI, MARTINNA M.; RANGEL, ELIDIANE C.; BARAO, VALENTIM A. R.. Optimizing citric acid protocol to control implant-related infections: An in vitro and in situ study. JOURNAL OF PERIODONTAL RESEARCH, v. 56, n. 3, . (17/01320-0, 18/14117-0)
CORDEIRO, JAIRO M.; NAGAY, BRUNA E.; DINI, CAROLINE; SOUZA, JOAO G. S.; RANGEL, ELIDIANE C.; DA CRUZ, NILSON C.; YANG, FANG; VAN DEN BEUCKEN, JEROEN J. J. P.; BARAO, VALENTIM A. R.. Copper source determines chemistry and topography of implant coatings to optimally couple cellular responses and antibacterial activity. BIOMATERIALS ADVANCES, v. 134, p. 13-pg., . (18/14117-0, 17/01320-0)
CORDEIRO, JAIRO M.; BARAO, VALENTIM A. R.; DE AVILA, ERICA D.; HUSCH, JOHANNA F. A.; YANG, FANG; VAN DEN BEUCKEN, JEROEN J. J. P.. Tailoring Cu2+-loaded electrospun membranes with antibacterial ability for guided bone regeneration. BIOMATERIALS ADVANCES, v. 139, p. 12-pg., . (18/14117-0, 17/01320-0)
DINI, CAROLINE; NAGAY, BRUNA E.; CORDEIRO, JAIRO M.; DA CRUZ, NILSON C.; RANGEL, ELIDIANE C.; RICOMINI-FILHO, ANTONIO P.; DE AVILA, ERICA D.; BARAO, VALENTIM A. R.. UV-photofunctionalization of a biomimetic coating for dental implants application. Materials Science & Engineering C-Materials for Biological Applications, v. 110, . (16/11470-6, 17/01320-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CORDEIRO, Jairo Matozinho. Development of antimicrobial biomaterials functionalized with copper for dental application. 2021. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

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