In vitro bioaccessibility assessment and in vivo bioavailability of arsenic ingested through rice commonly consumed by Brazilians

• Grant number: 16/19924-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2017
• End date: July 31, 2020
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Bruno Lemos Batista
• Grantee: Tatiana Pedron
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• Associated research grant: 14/05151-0 - Arsenic and rice: monitoring and (bio)remediation studies for food safety, AP.JP

Abstract

Essential elements such as arsenic (As) are detected in rice grains in several regions of the world, which may pose risks to human health because it is a toxic element even at low concentrations. Once rice cultivated under anaerobic conditions (flooded system) absorb about 4 times more As than under aerobic conditions (highlands). This accumulation is an issue of concerning once As is carcinogenic to humans. Several studies have been conducted to determine the As concentrations not only in rice but in many foods rice-containing. In humans, the main site of As uptake is the gastrointestinal tract once the main route of exposure are foods. Into the human body, As can be biotrasformed by the gastrointestinal cells or metabolized by the liver and thus conducted by the bloodstream to other organs and tissues causing deleterious effects. There are several studies in vitro and in vivo involving animals, however tests involving humans are scarcely. Evaluation of As effects on humans through rice naturally contaminated is important, since many factors can influence the bioavailability of As. Therefore, this project aims to evaluate the in vitro bioaccessibility and in vivo bioavailability in volunteers under rice-diet commonly consumed by Brazilians (purchased from supermarket). (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEDRON, TATIANA; SEGURA, FABIANA ROBERTA; PANIZ, FERNANDA POLIO; SOUZ, FELIPE DE MOURA; DOS SANTOS, MAURO COELHO; DE MAGALHAES JUNIOR, ARIANO MARTINS; BATISTA, BRUNO LEMOS. Mitigation of arsenic in rice grains by polishing and washing: Evidencing the benefit and the cost. JOURNAL OF CEREAL SCIENCE, v. 87, p. 52-58, MAY 2019. (16/19924-6, 15/06674-9, 14/05151-0, 17/22976-0, 16/10060-9, 18/06870-0, 17/21846-6)

PEDRON, TATIANA; OLIVEIRA, GREIZIANY SOARES PAULINO; PANIZ, FERNANDA POLLO; SOUZA, FELIPE DE MOURA; MASUDA, HANA PAULA; DOS SANTOS, MAURO COELHO; ROCHA, BRUNO ALVES; PEREIRA, RODRIGO MENDES; BATISTA, BRUNO LEMOS. Determination of chemical elements in rice from Singapore markets: Distribution, estimated intake and differentiation of rice varieties. Journal of Food Composition and Analysis, v. 101, AUG 2021. (16/19924-6, 14/05151-0, 17/10118-0, 17/21846-6, 16/10060-9)

PANIZ, FERNANDA POLLO; PEDRON, TATIANA; FREIRE, BRUNA MOREIRA; TORRES, DAIANE PLACIDO; SILVA, FABIO FERREIRA; BATISTA, BRUNO LEMOS. Effective procedures for the determination of As, Cd, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, Th, Zn, U and rare earth elements in plants and foodstuffs. ANALYTICAL METHODS, v. 10, n. 33, p. 4094-4103, SEP 7 2018. (16/19924-6, 14/05151-0, 16/10060-9, 18/06870-0)

PEDRON, TATIANA; FREIRE, BRUNA MOREIRA; CASTRO, CARLOS EDUARDO; RIBAL, LUIZ FELIPE; BATISTA, BRUNO LEMOS. Availability of arsenic in rice grains by in vitro and in vivo (humans) assays. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 56, p. 184-191, DEC 2019. (17/20914-8, 16/10060-9, 14/05151-0, 16/19924-6)

DA SILVA, JAQUELINE TROMBETTA; PANIZ, FERNANDA POLLO; SANCHEZ, FABIANA E SILVA; PEDRON, TATIANA; TORRES, DAIANE PLACIDO; GARCIA DA ROCHA CONCENCO, FERNANDA IZABEL; BARBAT PARFITT, JOSE MARIA; BATISTA, BRUNO LEMOS. Selected soil water tensions at phenological phases and mineral content of trace elements in rice grains - mitigating arsenic by water management. Agricultural Water Management, v. 228, FEB 20 2020. (16/19924-6, 14/05151-0)

FREIRE, BRUNA MOREIRA; GONZAGA, ROBERTA GRANJA; PEDRON, TATIANA; MONTEIRO, LUCILENA REBELO; LANGE, CAMILA NEVES; PEDREIRA FILHO, WALTER DOS REIS; BATISTA, BRUNO LEMOS. Occupational exposure to potentially toxic elements in the foundry industry: an integrated environmental and biological monitoring. Environmental Science and Pollution Research, v. 28, n. 26, SI, p. 34630-34641, JUL 2021. (16/19924-6, 17/20914-8, 20/00284-2, 16/10060-9, 14/05151-0)

SOUZA, FELIPE DE MOURA; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; DOS SANTOS, MAURO COELHO; BATISTA, BRUNO LEMOS. A high-throughput analytical tool for quantification of 15 metallic nanoparticles supported on carbon black. HELIYON, v. 5, n. 3, MAR 2019. (17/22976-0, 16/19924-6, 17/10118-0, 16/10060-9, 14/05151-0, 18/06870-0, 17/21846-6)

MONTEIRO, LUCILENA REBELO; LANGE, CAMILA NEVES; FREIRE, BRUNA MOREIRA; PEDRON, TATIANA; CENTENO DA SILVA, JULIO JOSE; DE MAGALHAES JUNIOR, ARIANO MARTINS; PEGORARO, CAMILA; BUSANELLO, CARLOS; BATISTA, BRUNO LEMOS. Inter- and intra-variability in the mineral content of rice varieties grown in various microclimatic regions of southern Brazil. Journal of Food Composition and Analysis, v. 92, SEP 2020. (14/05151-0, 16/19924-6)

FREIRE, BRUNA MOREIRA; PANIZ, FERNANDA POLLO; LANGE, CAMILA NEVES; PEDRON, TATIANA; DA SILVA, JAQUELINE TROMBETTA; SANCHEZ, FABIANA E SILVA; PARFITT, JOSE MARIA BARBAT; BATISTA, BRUNO LEMOS. Effect of water management on human exposure to inorganic arsenic and other trace elements through rice consumption. Journal of Food Composition and Analysis, v. 122, p. 11-pg., 2023-06-16. (22/04254-6, 14/05151-0, 16/10060-9, 16/19924-6, 20/00284-2)