Synthesis of PHPMA-b-PDPA, PEO-b-PDPA and RGD-PHPMA-b-PDPA conjugates with further engineering of pH-responsive polymersomes towards the encapsulation and delivery of hydrophilic biomacromolecules

• Grant number: 17/11261-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: October 01, 2017
• End date: September 30, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Fernando Carlos Giacomelli
• Grantee: Lindomar Jose Calumby Albuquerque
• Supervisor: Petr Stepanek
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Institution abroad: Czech Academy of Sciences (CAS), Czech Republic
• Associated to the scholarship: 16/23844-8 - Biodegradable and pH-responsive polymersomes for gene and protein delivery, BP.DR

Abstract

The pH-induced self-assembly approach will be employed to produce the supramolecular structures. Besides the whole scattering characterization scheduled to be performed in Brazil, cryo-TEM imaging will be performed in the Institute of Macromolecular Chemistry to shed light on the morphology of the produced assemblies. This particular experimental tool is not available in Brazil. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JAGER, ELIEZER; SINCARI, VLADIMIR; ALBUQUERQUE, LINDOMAR J. C.; JAGER, ALESSANDRO; HUMAJOVA, JANA; KUCKA, JAN; PANKRAC, JAN; PARAL, PETR; HEIZER, TOMAS; JANOUSKOVA, OLGA; et al. Reactive Oxygen Species (ROS)-Responsive Polymersomes with Site-Specific Chemotherapeutic Delivery into Tumors via Spacer Design Chemistry. Biomacromolecules, v. 21, n. 4, p. 1437-1449, APR 2020. (17/00459-4, 17/11261-0)

CERNOCH, PETER; JAGER, ALESSANDRO; CERNOCHOVA, ZULFIYA; SINCARI, VLADIMIR; ALBUQUERQUE, LINDOMAR J. C.; KONEFAL, RAFAL; PAVLOVA, EWA; GIACOMELLI, FERNANDO C.; JAGER, ELIEZER. Engineering of pH-triggered nanoplatforms based on novel poly(2-methyl-2-oxazoline)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymers with tunable morphologies for biomedical applications. Polymer Chemistry, v. 12, n. 19, p. 2868-2880, MAY 21 2021. (19/06634-8, 16/23844-8, 17/11261-0)

ALBUQUERQUE, LINDOMAR J. C.; SINCARI, VLADIMIR; JAGER, ALESSANDRO; KONEFAL, RAFAL; PANEK, JIRI; CERNOCH, PETER; PAVLOVA, EWA; STEPANEK, PETR; GIACOMELLI, FERNANDO C.; JAGER, ELIEZER. Microfluidic-Assisted Engineering of Quasi-Monodisperse pH-Responsive Polymersomes toward Advanced Platforms for the Intracellular Delivery of Hydrophilic Therapeutics. Langmuir, v. 35, n. 25, p. 8363-8372, JUN 25 2019. (17/11261-0, 17/00459-4)