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Effects of nicotinamide Riboside supplementation and aerobic training on mitonuclear imbalance and on mitochondrial UPR in the hypothalamus of mice

Grant number: 17/18695-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Biological Sciences - Physiology - Physiology of Effort
Principal Investigator:Eduardo Rochete Ropelle
Grantee:Renata Rosseto Braga
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil

Abstract

Recent studies indicate that the maintenance of mitochondrial activity in hypothalamic neurons is a determinant for the control of energy homeostasis in mammals. It is known that the abundance of NAD + levels induces potent mitochondrial signals, promoting increased oxidative capacity and increased mitochondrial biogenesis. Among these signs, we highlight the induction of "mitonuclear imbalance" and the activation of UPRmt, from the English unfolded protein response. "Mitonuclear imbalance" and UPRmt are highly conserved mechanisms among species and essential for reestablishing proteostase within mitochondria, allowing cells to survive under stress, by increasing the number and efficiency of mitochondria. In this scenario, we hypothesized that oral treatment with Nicotinamide Riboside (NR), a precursor of NAD +, or physical exercise, a physiological stimulator of NAD + levels, may trigger mitonuclear imbalance and UPRmt activation in the hypothalamus of Mice, stimulating mitochondrial biogenesis in hypothalamic neurons, which contribute to the control of energy homeostasis. (AU)