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Influence of aerobic physical training on cardiac remodeling of spontaneously hypertensive rats treated with dexamethasone

Grant number: 17/14405-3
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2018
Effective date (End): February 28, 2019
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Sandra Lia do Amaral Cardoso
Grantee:Francine Duchatsch Ribeiro de Souza
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Heart failure (HF) is one of the most deadly cardiovascular diseases in Brazil. Cardiac hypertrophy, increased fibrosis and capillary density reduction are implicated in its development. Spontaneously hypertensive rats (SHR), throughout their life, develop cardiac hypertrophy due to arterial hypertension (HA) evolution. However, little is known about dexamethasone-effects (DEX) in these animals, since DEX-chronic treatment provokes HA and cardiac hypertrophy. On the other hand, aerobic physical training (T) has been used as non-pharmacological treatment of HA and one of its mechanisms is cardiac remodeling alterations. The hypothesis of this study is that DEX may promote a highest increase in blood pressure (BP) and worse the cardiac remodeling process in SHR. On the other hand, T may be able to mitigate these deleterious effects of DEX. Therefore, the objective of the present study will be to investigate whether DEX-treatment worsens cardiac remodeling process in SHR and if T attenuates this response. For this, SHR will perform 8-weeks of T on the treadmill (60% of the maximum capacity, 5 days per week, 1 hour per day) or remain sedentary. Wistar sedentary rats will be used as control. During the following 14 days, after 8 weeks of T, animals will be treated with DEX (50 ¼g / kg of body weight per day, s.c.) or saline. Before and after the experimental protocol, these animals will be submitted to an echocardiogram examination. At the end of the experimental protocol, heart rate (HR) and direct blood pressure (BP) will be measured by carotid artery catheterization and spectral analysis will be performed. After, heart will be removed for capillary density analysis, myocyte diameter, type I and III collagen localization and analysis of protein production. The results will be presented as mean ± standard error of the mean (SEM). One way variance analysis (ANOVA) and Tukey post-hoc, with p <0,05. (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIOTTO, DANYELLE S.; DUCHATSCH, FRANCINE; MACEDO, ANDERSON G.; RUIZ, THALLES F. R.; VICENTINI, CARLOS A.; AMARAL, SANDRA L. Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats. Journal of Cardiovascular Pharmacology, v. 77, n. 4, p. 519-528, APR 2021. Web of Science Citations: 0.
TARDELLI, LIDIELI P.; DUCHATSCH, FRANCINE; HERRERA, NAIARA A.; VICENTINI, CARLOS ALBERTO; OKOSHI, KATASHI; AMARAL, SANDRA L. Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats. JOURNAL OF APPLIED TOXICOLOGY, FEB 2021. Web of Science Citations: 0.
HERRERA, NAIARA A.; DUCHATSCH, FRANCINE; TARDELLI, LIDIELI P.; DIONISIO, THIAGO J.; SANTOS, CARLOS F.; AMARAL, SANDRA L. Dexamethasone Does Not Inhibit Treadmill Training-Induced Angiogenesis in Myocardium: Role of MicroRNA-126 Pathway. Journal of Cardiovascular Pharmacology, v. 76, n. 6, p. 708-714, DEC 2020. Web of Science Citations: 1.
DUCHATSCH, FRANCINE; TARDELLI, LIDIELI P.; HERRERA, NAIARA A.; RUIZ, THALLES F. R.; VICENTINI, CARLOS A.; OKOSHI, KATASHI; SANTOS, CARLOS F.; AMARAL, SANDRA L. Dexamethasone and Training-Induced Cardiac Remodeling Improve Cardiac Function and Arterial Pressure in Spontaneously Hypertensive Rats. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, v. 26, n. 2 AUG 2020. Web of Science Citations: 1.
HERRERA, NAIARA ARAUJO; DUCHATSCH, FRANCINE; KAHLKE, ALLISON; AMARAL, SANDRA LIA; VASQUEZ-VIVAR, JEANNETTE. In vivo vascular rarefaction and hypertension induced by dexamethasone are related to phosphatase PTP1B activation not endothelial metabolic changes. Free Radical Biology and Medicine, v. 152, p. 689-696, MAY 20 2020. Web of Science Citations: 0.
HERRERA, NAIARA A.; DUCHATSCH, FRANCINE; TARDELLI, LIDIELI P.; DIONISIO, THIAGO J.; SHINOHARA, ANDRE L.; SANTOS, CARLOS F.; AMARAL, SANDRA LIA. MicroRNA-126 upregulation, induced by training, plays a role in controlling microcirculation in dexamethasone treated rats. Molecular and Cellular Endocrinology, v. 505, APR 5 2020. Web of Science Citations: 0.

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