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Evaluation of synergic effect between CHC and cetuximab against glioblastoma using drug delivery systems

Grant number: 18/04546-1
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 28, 2018
Effective date (End): September 27, 2018
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Maria Palmira Daflon Gremião
Grantee:Natália Noronha Ferreira Naddeo
Supervisor abroad: Maria de Fatima Monginho Baltazar
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Local de pesquisa : Universidade do Minho (UMinho), Portugal  
Associated to the scholarship:16/09671-3 - Nanostructured multifunctional systems for drug controlled release through nasal route on glioblastomas treatment, BP.DR


Glioblastomas (GBM) account 77% of malignant tumors that occurs on central nervous system (SNC) and today, despite all advances in chemotherapy, radiotherapy and neurosurgery, remains with limited prognosis. The existence of physiological barriers, especially blood brain barrier (BBB), represents the main obstacle that limits adequate concentrations of the drugs designed to therapy. Due to their anatomical advantages, a strategy proposed for appropriate delivery to SNC involves the use of the nasal route of administration once it avoids the passage through the BBB, allowing sufficient drug concentrations to reach the brain by perineural channels. Little changes and survival improvements with resection thresholds have been reported through the use of associated therapies for cancer treatment. A multiple target approach might provide simultaneous interference on different signaling pathways, minimizing the occurrence of resistance. Although a series of therapy protocols using combined drugs have been tested, association aiming to inhibit epidermal grow factor receptor together with monocarboxylate transporters have not yet been attempted. We hypothesized that two already studied drugs (±-cyano-4-hydroxycinnamic acid and cetuximab) could synergize against GBM. Therefore, we proposed a new "double combination" therapeutic strategy against GBM, a possibility given by the development of polymeric drug delivery systems to be administered by the nasal route. Nanotechnology integrates this research giving technological tools that can provide selective drug delivery, facilitating drug internalization and promoting drug controlled release to the intracellular target.