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EVALUATION OF SYNERGIC EFFECT BETWEEN CHC AND CETUXIMAB AGAINST GLIOBLASTOMA USING DRUG DELIVERY SYSTEMS

Grant number: 18/04546-1
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 28, 2018
Effective date (End): September 27, 2018
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Maria Palmira Daflon Gremião
Grantee:Natália Noronha Ferreira Naddeo
Supervisor abroad: Maria de Fatima Monginho Baltazar
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: Universidade do Minho (UMinho), Portugal  
Associated to the scholarship:16/09671-3 - Nanostructured multifunctional systems for drug controlled release through nasal route on glioblastomas treatment, BP.DR

Abstract

Glioblastomas (GBM) account 77% of malignant tumors that occurs on central nervous system (SNC) and today, despite all advances in chemotherapy, radiotherapy and neurosurgery, remains with limited prognosis. The existence of physiological barriers, especially blood brain barrier (BBB), represents the main obstacle that limits adequate concentrations of the drugs designed to therapy. Due to their anatomical advantages, a strategy proposed for appropriate delivery to SNC involves the use of the nasal route of administration once it avoids the passage through the BBB, allowing sufficient drug concentrations to reach the brain by perineural channels. Little changes and survival improvements with resection thresholds have been reported through the use of associated therapies for cancer treatment. A multiple target approach might provide simultaneous interference on different signaling pathways, minimizing the occurrence of resistance. Although a series of therapy protocols using combined drugs have been tested, association aiming to inhibit epidermal grow factor receptor together with monocarboxylate transporters have not yet been attempted. We hypothesized that two already studied drugs (±-cyano-4-hydroxycinnamic acid and cetuximab) could synergize against GBM. Therefore, we proposed a new "double combination" therapeutic strategy against GBM, a possibility given by the development of polymeric drug delivery systems to be administered by the nasal route. Nanotechnology integrates this research giving technological tools that can provide selective drug delivery, facilitating drug internalization and promoting drug controlled release to the intracellular target.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO DE SOUZA, ANA LUIZA; FERREIRA AMORIM, AMANDA CLAUDIA; CINTRA, EMILIO RAMOS; FERREIRA, NATALIA NORONHA; DANTAS SILVA, LUIS ANTONIO; HAYASAKI, TACIO GONCALVES; ALMEIDA DINIZ, DANIELLE GUIMARAES; LIMA, ELIANA MARTINS. Development and validation of a rapid RP-HPLC method for simultaneous quantification of paclitaxel and cetuximab in immunoliposomes. Talanta, v. 225, APR 1 2021. Web of Science Citations: 0.
VICTORELLI, FRANCESCA DAMIANI; DE OLIVEIRA CARDOSO, VALERIA MARIA; FERREIRA, NATALIA NORONHA; FIORAMONTI CALIXTO, GIOVANA MARIA; FONTANA, CARLA RAQUEL; BALTAZAR, FATIMA; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 153, p. 273-284, AUG 2020. Web of Science Citations: 0.
FERREIRA, NATALIA N.; GRANJA, SARA; BONI, FERNANDA ISADORA; FERREIRA, LEONARDO M. B.; REIS, RUI M.; BALTAZAR, FATIMA; GREMIAO, MARIA PALMIRA D. A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 3, SI JAN 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.