Evaluation of synergic effect between CHC and cetuximab against glioblastoma using drug delivery systems

• Grant number: 18/04546-1
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Effective date (Start): May 28, 2018
• Effective date (End): September 27, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Maria Palmira Daflon Gremião
• Grantee: Natália Noronha Ferreira Naddeo
• Supervisor: Maria de Fatima Monginho Baltazar
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Research place: Universidade do Minho (UMinho), Portugal
• Associated to the scholarship: 16/09671-3 - Nanostructured multifunctional systems for drug controlled release through nasal route on glioblastomas treatment, BP.DR

Abstract

Glioblastomas (GBM) account 77% of malignant tumors that occurs on central nervous system (SNC) and today, despite all advances in chemotherapy, radiotherapy and neurosurgery, remains with limited prognosis. The existence of physiological barriers, especially blood brain barrier (BBB), represents the main obstacle that limits adequate concentrations of the drugs designed to therapy. Due to their anatomical advantages, a strategy proposed for appropriate delivery to SNC involves the use of the nasal route of administration once it avoids the passage through the BBB, allowing sufficient drug concentrations to reach the brain by perineural channels. Little changes and survival improvements with resection thresholds have been reported through the use of associated therapies for cancer treatment. A multiple target approach might provide simultaneous interference on different signaling pathways, minimizing the occurrence of resistance. Although a series of therapy protocols using combined drugs have been tested, association aiming to inhibit epidermal grow factor receptor together with monocarboxylate transporters have not yet been attempted. We hypothesized that two already studied drugs (±-cyano-4-hydroxycinnamic acid and cetuximab) could synergize against GBM. Therefore, we proposed a new "double combination" therapeutic strategy against GBM, a possibility given by the development of polymeric drug delivery systems to be administered by the nasal route. Nanotechnology integrates this research giving technological tools that can provide selective drug delivery, facilitating drug internalization and promoting drug controlled release to the intracellular target.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, NATALIA N.; GRANJA, SARA; BONI, FERNANDA ISADORA; FERREIRA, LEONARDO M. B.; REIS, RUI M.; BALTAZAR, FATIMA; GREMIAO, MARIA PALMIRA D.. A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 3, SI, JAN 2020. (18/04546-1, 17/16324-0, 16/09671-3)

VICTORELLI, FRANCESCA DAMIANI; DE OLIVEIRA CARDOSO, VALERIA MARIA; FERREIRA, NATALIA NORONHA; FIORAMONTI CALIXTO, GIOVANA MARIA; FONTANA, CARLA RAQUEL; BALTAZAR, FATIMA; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 153, p. 273-284, AUG 2020. (14/50928-2, 19/07245-5, 18/04546-1, 13/01565-1, 16/09671-3, 15/21412-0, 16/06337-5, 17/10016-2, 17/23357-2)

DE OLIVEIRA CARDOSO, VALERIA MARIA; PEREIRA DE BRITO, NATALIA ARAUJO; FERREIRA, NATALIA NORONHA; BONI, FERNANDA ISADORA; BARBOZA FERREIRA, LEONARDO MIZIARA; CARVALHO, SUZANA GONCALVES; DAFLON GREMIAO, MARIA PALMIRA. Design of mucoadhesive gellan gum and chitosan nanoparticles intended for colon-specific delivery of peptide drugs. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 628, NOV 5 2021. (14/50928-2, 16/09671-3, 15/21412-0, 18/04546-1)

RIBEIRO DE SOUZA, ANA LUIZA; FERREIRA AMORIM, AMANDA CLAUDIA; CINTRA, EMILIO RAMOS; FERREIRA, NATALIA NORONHA; DANTAS SILVA, LUIS ANTONIO; HAYASAKI, TACIO GONCALVES; ALMEIDA DINIZ, DANIELLE GUIMARAES; LIMA, ELIANA MARTINS. Development and validation of a rapid RP-HPLC method for simultaneous quantification of paclitaxel and cetuximab in immunoliposomes. Talanta, v. 225, APR 1 2021. (18/04546-1, 16/09671-3)