Analysis of the influence of the landscape on the population structure of mosquitoes Haemagogus (Conopostegus) leucocelaenus (Diptera: Culicidae) in areas with historical of Yellow Fever epizootics in non-human primates in the State of São Paulo

• Grant number: 17/23127-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): May 01, 2018
• Effective date (End): April 30, 2022
• Field of knowledge: Biological Sciences - Parasitology - Entomology and Malacology of Parasites and Vectors
• Principal Investigator: Mauro Toledo Marrelli
• Grantee: Ramon Wilk da Silva
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Yellow Fever (YF) is an infectious disease caused by Yellow Fever Virus (YFV) and carried by mosquitoes of the Culicidae family. In Brazil and other South American countries, it has been restricted to the wild cycle, with the last urban epidemic in Brazil occurred in 1928, associated with the Aedes aegypti. In South and Southeastern Brazil, the species Haemagogus leucocelaenus has been implicated as the main vector of wild Yellow Fever, since individuals of this species have often been found naturally infected by YFV in epizootic areas. Currently, Brazil suffers from its worst outbreak of Yellow Fever in the last decades, with several records of epizootics and human cases in several regions of the country, including the State of São Paulo. The fragmentation of the landscape, as a function of human activity, is one of the main causes of loss of biodiversity and among others; we can highlight its contribution in changing the epidemiological patterns of diseases, mainly due to changes in levels of interactions, abundance and movement of hosts, vectors and people. Thus, understanding its effect on vector populations implicated in the transmission of Yellow Fever, such as the Hg. leucocelaenus, may mean a better understanding of circulation pattern of the YFV in areas with historical of epizootics, aiding in more control measures effective. Therefore, the present project aims to investigate the influence of the landscape on the population structure of Hg. leucocelaenus mosquitoes in areas with historical of Yellow Fever epizootics in non-human primates, located in the state of São Paulo. For this, single nucleotide polymorphism markers will be used to characterize the population structure of Hg. leucocelaenus. Mosquitoes will be collected in areas with recent and non-recent historical of Yellow Fever epizootics in non-human primates. For each collection site, we intend to classify and measure landscape metrics that will be used to investigate possible associations with genotypic variations in the vector populations. We expected that with this study it would be possible to identify how changes in the landscape can influence their population structure and gene flow, since such a process may reflect on the circulation pattern of the virus in the environment. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

WILK-DA-SILVA, RAMON; MUCCI, LUIS FILIPE; CERETTI-JUNIOR, WALTER; RIBEIRO DE CASTRO DUARTE, ANA MARIA; MARRELLI, MAURO TOLEDO; MEDEIROS-SOUSA, ANTONIO RALPH. Influence of landscape composition and configuration on the richness and abundance of potential sylvatic yellow fever vectors in a remnant of Atlantic Forest in the city of Sao Paulo, Brazil. Acta Tropica, v. 204, APR 2020. (17/23127-7)

WILK-DA-SILVA, RAMON; MEDERIROS-SOUSA, ANTONIO RALPH; LAPORTA, GABRIEL ZORELLO; MUCCI, LUIS FILIPE; PRIST, PAULA RIBEIRO; MARRELLI, MAURO TOLEDO. The influence of landscape structure on the dispersal pattern of yellow fever virus in the state of Sao Paulo. Acta Tropica, v. 228, p. 9-pg., 2022-02-01. (18/18751-6, 17/23127-7, 18/25437-6)

OLIVEIRA-CHRISTE, RAFAEL; DE CARVALHO, GABRIELA CRISTINA; WILKE, ANDRE BARRETTO BRUNO; MARRELLI, MAURO TOLEDO. Assessment of wing geometric morphometrics of urban Culex quinquefasciatus (Diptera: Culicidae) populations. Acta Tropica, v. 245, p. 7-pg., 2023-06-20. (18/25437-6, 17/23127-7, 18/18751-6)

WILK-DA-SILVA, RAMON; PRIST, PAULA RIBEIRO; MEDEIROS-SOUSA, ANTONIO RALPH; LAPORTA, GABRIEL ZORELLO; MUCCI, LUIS FILIPE; MARRELLI, MAURO TOLEDO. The role of forest fragmentation in yellow fever virus dispersal. Acta Tropica, v. 245, p. 9-pg., 2023-09-01. (18/25437-6, 17/23127-7, 18/18751-6)

WILK-DA-SILVA, RAMON; MEDEIROS-SOUSA, ANTONIO RALPH; MUCCI, LUIS FILIPE; ALONSO, DIEGO PERES; ALVAREZ, MARCUS VINICIUS NIZ; RIBOLLA, PAULO EDUARDO MARTINS; MARRELLI, MAURO TOLEDO. Genetic Structuring of One of the Main Vectors of Sylvatic Yellow Fever: Haemagogus (Conopostegus) leucocelaenus (Diptera: Culicidae). GENES, v. 14, n. 9, p. 16-pg., 2023-09-01. (18/25437-6, 17/23127-7, 18/18751-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Ramon Wilk da. Landscape influence analysis in the population structure of Haemagogus (Conopostegus) leucocelaenus (Diptera: Culicidae) from areas with yellow fever epizootics in non-human primates in the state of São Paulo. 2022. Doctoral Thesis - Faculdade de Medicina (FM/SBD) São Paulo.