Influence of the propolis use on the metabolic profile of HIV-infected individuals treated with antiretroviral therapy

• Grant number: 18/04297-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2018
• End date: November 30, 2019
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Karen Ingrid Tasca
• Grantee: Ana Claudia de Moura Moreira Alves
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Although antiretroviral therapy has improved the life expectancy of people living with HIV/AIDS, it is associated with several adverse effects such as changes in metabolic profile and in body composition, factors that contribute to the development of non-AIDS diseases, such as diabetes and hypertension. Propolis, a natural product with no side effects described in the literature, has antioxidant and anti-inflammatory properties and therefore, presents great potential to bring improvements in the health of the HIV-infected people. Thus, the objective of this study is to verify if the metabolic profile of these individuals can be improved with the daily use of propolis. For this, we will perform a randomized double-blind clinical trial study, with parallel intervention for 12 weeks in 40 HIV-infected patients. The analyzed variables will be: TCD4 + cell count, TCD8 +, triglycerides, total cholesterol and fractions, as well as anthropometric evaluation by measures of weight, height, neck, waist, hip and arm circumferences; nutritional diagnosis by BMI; evaluation of body composition by multifrequency electrical bioimpedance and; evaluation of the food profile through the 24-hour dietary recall and food registry. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONTE, FERNANDA LOPES; TASCA, KAREN INGRID; SANTIAGO, KARINA BASSO; CARDOSO, ELIZA DE OLIVEIRA; ROMAGNOLI, GRAZIELA GORETE; GOLIM, MARJORIE DE ASSIS; MARQUES BRAZ, ALINE MARCIA; BERRETTA, ANDRESA APARECIDA; DE SOUZA, LENICE DO ROSARIO; SFORCIN, JOSE MAURICIO. Propolis increases Foxp(3) expression and lymphocyte proliferation in HIV-infected people: A randomized, double blind, parallel-group and placebo-controlled study. BIOMEDICINE & PHARMACOTHERAPY, v. 142, OCT 2021. (17/14846-0, 16/24591-6, 18/04297-1)

TASCA, KAREN INGRID; CONTE, FERNANDA LOPES; CORREA, CAMILA RENATA; SANTIAGO, KARINA BASSO; CARDOSO, ELIZA DE OLIVEIRA; MANFIO, VANESSA MARTINEZ; GARCIA, JESSICA LEITE; BERRETTA, ANDRESA APARECIDA; SARTORI, ARTHUR ALVES; HONORIO, MARIANA DA SILVA; et al. Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial. BIOMEDICINE & PHARMACOTHERAPY, v. 162, p. 7-pg., 2023-06-01. (17/14846-0, 18/04297-1)