Modification of the temperature transition profile of thermosensitive nanocomposites

• Grant number: 18/12871-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: October 01, 2018
• End date: January 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Emerson Rodrigues de Camargo
• Grantee: Lucas da Silva Ribeiro
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID
• Associated scholarship(s): 21/10844-8 - Development of thermosensitive nanocomposite hydrogels for the pro-osteogenic differentiation of stem cells using naringin, BE.EP.DD

Abstract

In recent years, research focused on the development of biomaterials, such as injectable hydrogels for use in non-invasive surgeries and with potential use as a means of transportation and controlled drug release, has been intensified. Among them, poly (N-vinylcaprolactam) (PNVCL) may form biocompatible hydrogels with chemical and mechanical properties suitable for use as implants. A promising alternative in the field of biomaterials is the preparation of nanocomposites that associate the properties of the polymers with the mechanical resistance of bioactive ceramics, such as silica nanoparticles. In this way, nanocomposites of thermosensitive polymers of PNVCL with different compositions of SiO2 nanoparticles of different sizes and concentrations will be prepared in this project, seeking to obtain new biomaterials for the transportation and controlled release of drugs. In order to evaluate the morphology, structure and thermal properties of hydrogels, nanoparticles and nanocomposites, scanning and transmission electron microscopy techniques, dynamic light scattering, infrared absorption spectroscopy, Differential Calorimetry Scanning (DSC) and thermogravimetry (TGA). Finally, by UV-vis spectrophotometry, the analysis of the Lower Critical Solubilization Temperature (LCST) from its thermodynamic parameters and the kinetic study of the release of dyes and antibiotics will be carried out. (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIBEIRO, LUCAS S.; NOGUEIRA, ANDRE E.; AQUINO, JOSE M.; CAMARGO, EMERSON R.. A new strategy to obtain nano-scale particles of lithium titanate (Li4Ti5O12) by the oxidant peroxo method (OPM). CERAMICS INTERNATIONAL, v. 45, n. 18, A, p. 23917-23923, DEC 15 2019. (16/14667-5, 13/07296-2, 18/12871-0, 14/25616-7, 14/09014-7, 15/13958-3)

RIBEIRO, LUCAS S.; SALA, RENATA L.; DE JESUS, LETICIA A. O.; CRUZ, SANDRA A.; CAMARGO, EMERSON R.. Analyzing the Effects of Silica Nanospheres on the Sol-Gel Transition Profile of Thermosensitive Hydrogels. Langmuir, v. 37, n. 24, p. 7373-7379, JUN 22 2021. (13/25663-2, 18/12871-0, 13/07296-2, 14/09014-7)

RIBEIRO, LUCAS S.; SALA, RENATA L.; ROBELDO, THAIANE A.; BORRA, RICARDO C.; CAMARGO, EMERSON R.. Injectable Thermosensitive Nanocomposites Based on Poly(N-vinylcaprolactam) and Silica Particles for Localized Release of Hydrophilic and Hydrophobic Drugs. Langmuir, v. N/A, p. 9-pg., 2023-02-06. (13/07296-2, 18/12871-0, 13/25663-2)

RIBEIRO, LUCAS S. S.; GASPAR, VITOR M.; SOBREIRO-ALMEIDA, RITA; CAMARGO, EMERSON R. R.; MANO, JOAO F.. Programmable Granular Hydrogel Inks for 3D Bioprinting Applications. ADVANCED MATERIALS TECHNOLOGIES, v. N/A, p. 15-pg., 2023-06-16. (21/10844-8, 13/07296-2, 18/12871-0)

BRAGA, GABRIELA PACHECO DE ALMEIDA; CAIAFFA, KARINA SAMPAIO; RABELO, RAFAELA LARUZO; DOS SANTOS, VANESSA RODRIGUES; SOUZA, AMANDA CASELATO ANDOLFATTO; RIBEIRO, LUCAS DA SILVA; DE CAMARGO, EMERSON RODRIGUES; PRAKKI, ANURADHA; DUQUE, CRISTIANE. Cytotoxicity and Biomineralization Potential of Flavonoids Incorporated into PNVCL Hydrogels. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 14, n. 3, p. 17-pg., 2023-03-01. (17/10940-1, 18/12871-0)

COSTA, LARISSA F.; RUOTOLO, LUIS A. M.; RIBEIRO, LUCAS S.; PEREIRA, MARCIO C.; CAMARGO, EMERSON R.; NOGUEIRA, FRANCISCO G. E.. Low-cost magnetic activated carbon with excellent capacity for organic adsorption obtained by a novel synthesis route. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 9, n. 2, p. 9-pg., 2021-01-21. (18/09723-9, 18/12871-0)

COSTA, LARISSA F.; RUOTOLO, LUIS A. M.; RIBEIRO, LUCAS S.; PEREIRA, MARCIO C.; CAMARGO, EMERSON R.; NOGUEIRA, FRANCISCO G. E.. Low-cost magnetic activated carbon with excellent capacity for organic adsorption obtained by a novel synthesis route. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 9, n. 2, APR 2021. (18/12871-0, 18/09723-9)

RIBEIRO, LUCAS S.; PINATTI, IVO M.; TORRES, JULIANA A.; GIROTO, AMANDA S.; LESSE, FABIANA; LONGO, ELSON; RIBEIRO, CAUE; NOGUEIRA, ANDRE E.. Rapid microwave-assisted hydrothermal synthesis of CuBi2O4 and its application for the artificial photosynthesis. Materials Letters, v. 275, SEP 15 2020. (16/21515-7, 18/10104-1, 18/01258-5, 19/03722-3, 13/07296-2, 18/12871-0)

FARIA, ANA LUIZA A.; CENTURION, HIGOR A.; TORRES, JULIANA A.; GONCALVES, V, RENATO; RIBEIRO, LUCAS S.; RIBERIO, CAUE; DA CRUZ, JEAN C.; NOGUEIRA, FRANCISCO G. E.. Enhancing Nb2O5 activity for CO2 photoreduction through Cu nanoparticles cocatalyst deposited by DC-magnetron sputtering. JOURNAL OF CO2 UTILIZATION, v. 53, NOV 2021. (16/21515-7, 18/12871-0, 18/09723-9)

DE MORAES, AMANDA CAROLINA PRADO; RIBEIRO, LUCAS DA SILVA; DE CAMARGO, EMERSON RODRIGUES; LACAVA, PAULO TEIXEIRA. The potential of nanomaterials associated with plant growth-promoting bacteria in agriculture. 3 BIOTECH, v. 11, n. 7, JUL 2021. (15/10974-8, 18/12871-0)

BRAGA, GABRIELA PACHECO DE ALMEIDA; CAIAFFA, KARINA SAMPAIO; PEREIRA, JESSE AUGUSTO; DOS SANTOS, VANESSA RODRIGUES; SOUZA, AMANDA CASELATO ANDOLFATTO; RIBEIRO, LUCAS DA SILVA; CAMARGO, EMERSON RODRIGUES; PRAKKI, ANURADHA; DUQUE, CRISTIANE. Microbiological Properties and Cytotoxicity of PNVCL Hydrogels Containing Flavonoids as Intracanal Medication for Endodontic Therapy. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 13, n. 4, p. 16-pg., 2022-12-01. (17/10940-1, 18/12871-0)

RIBEIRO, LUCAS S.; NOGUEIRA, ANDRE E.; AQUINO, JOSE M.; CAMARGO, EMERSON R.. A new strategy to obtain nano-scale particles of lithium titanate (Li4Ti5O12) by the oxidant peroxo method (OPM). CERAMICS INTERNATIONAL, v. 45, n. 18, p. 7-pg., 2019-12-15. (16/14667-5, 15/13958-3, 14/25616-7, 13/07296-2, 18/12871-0, 14/09014-7)