Advanced search
Start date

Study on the variability of venom in snakes of the Bothrops jararaca complex and its correlation with the processes of speciation in continental islands

Grant number: 18/25749-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2019
Effective date (End): March 31, 2021
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Cooperation agreement: NSF - Dimensions of Biodiversity and BIOTA
Principal researcher:Inácio de Loiola Meirelles Junqueira de Azevedo
Grantee:José Antonio Portes Junior
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:16/50127-5 - Dimensions US-BIOTA São Paulo: scales of biodiversity: integrated studies of snake venom evolution and function across multiple levels of diversity, AP.BTA.TEM


The molecular mechanisms of adaptive evolution are little known. So far, it is not known how the complex evolutionary novelties are generated during the recent processes of speciation. Distinct phenotypic characteristics could arise due to changes in gene regulation or directional selection of mutations in the genes themselves. Isolated venomous snakes on islands are powerful models for studies on the evolutionary processes that generate phenotypic diversity. The venoms produced by the species of Bothrops jararaca complex are considered highly related to the availability of prey of the same. Populations of B. jararaca underwent several processes of recent speciation, in the continental islands of southeastern Brazil, making these island populations an extreme case of recent adaptation to distinct niches. This project aims to evaluate the complexity of venoms in both island and continental populations of the Bothrops jararaca complex in order to infer the importance of venom composition in the adaptation of these populations to the niche in which they are found. For this, we will analyze the chromatographic profiles of the individual venoms, generate the transcriptome of the venom glands and characterize the proteome of each venom by mass spectrometry analysis. Based on the results obtained, we will try to correlate the venom diversity to the demographic, biological and ecological parameters of the populations sampled. In this way, we will test the hypothesis that the rapid phenotypic differentiation between closely related species can be shaped by an intense process of natural selection, which would support theories of ecological speciation through the rapid adaptation to different niches.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HARRIS, RICHARD J.; YOUNGMAN, NICHOLAS J.; ZDENEK, CHRISTINA N.; HUYNH, TAM M.; NOUWENS, AMANDA; HODGSON, WAYNE C.; HARRICH, DAVID; DUNSTAN, NATHAN; PORTES-JUNIOR, JOSE A.; FRY, BRYAN G.. Assessing the Binding of Venoms from Aquatic Elapids to the Nicotinic Acetylcholine Receptor Orthosteric Site of Different Prey Models. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 19, . (18/25749-8)
FREITAS-DE-SOUSA, LUCIANA A.; NACHTIGALL, PEDRO G.; FORTES-JUNIOR, JOSE A.; HOLDING, MATTHEW L.; NYSTROM, GUNNAR S.; ELLSWORTH, SCHYLER A.; GUIMARIES, NORANATHAN C.; TIOYAMA, EMILLY; ORTIZ, FLORA; SILVA, BRUNO R.; et al. Size Matters: An Evaluation of the Molecular Basis of Ontogenetic Modifications in the Composition of Bothrops jararacussu Snake Venom. TOXINS, v. 12, n. 12, . (18/25749-8, 18/08589-7, 18/15753-8, 18/26520-4, 16/50127-5, 17/24546-3)
DASHEVSKY, DANIEL; BENARD-VALLE, MELISA; NERI-CASTRO, EDGAR; YOUNGMAN, NICHOLAS J.; ZDENEK, CHRISTINA N.; ALAGON, ALEJANDRO; PORTES-JUNIOR, JOSE A.; FRANK, NATHANIEL; FRY, BRYAN G.. Anticoagulant Micrurus venoms: Targets and neutralization. Toxicology Letters, v. 337, p. 91-97, . (18/25749-8)
BARBO, FAUSTO E.; BOOKER, WILLIAM W.; DUARTE, MARCELO R.; CHALUPPE, BETINA; PORTES-JUNIOR, JOSE A.; FRANCO, FRANCISCO L.; GRAZZIOTIN, FELIPE G.. peciation process on Brazilian continental islands, with the description of a new insular lancehead of the genus Bothrops (Serpentes, Viperidae. SYSTEMATICS AND BIODIVERSITY, v. 20, n. 1, p. 1-25, . (16/50127-5, 12/09156-0, 18/25749-8)
MOURA-DA-SILVA, ANA MARIA; CONTRERAS-BERNAL, JORGE CARLOS; GIMENES, SARAH NATALIE CIRILO; FREITAS-DE-SOUSA, LUCIANA APARECIDA; PORTES-JUNIOR, JOSE ANTONIO; PEIXOTO, PEDRO DA SILVA; IWAI, LEO KEI; DE MOURA, VALERIA MOURAO; BISNETO, PEDRO FERREIRA; LACERDA, MARCUS; et al. The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). PLoS Neglected Tropical Diseases, v. 14, n. 6, . (13/07467-1, 18/13108-8, 18/25749-8, 17/24546-3)

Please report errors in scientific publications list by writing to: