Plasma profile of short-chain fatty acids and body adiposity: associations with environmental factors in the first years of life in women's participants NutriHS - Nutritionist Health Study

• Grant number: 19/05450-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2019
• End date: June 30, 2020
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Ana Carolina Junqueira Vasques
• Grantee: Marina Gomes Barbosa
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

INTRODUCTION: Several studies show the association between adequate initial formation of the intestinal microbiota and health in adult life. In parallel, recent studies point to short-chain fatty acids as modulators of energetic, lipidic and glycemic homeostasis in peripheral organs. Considering the current obesity epidemic, it is important to understand the factors that formed the intestinal microbiota in early life and its relation to the plasma short-chain fatty acids and adult adiposity profiles. PURPOSE: To investigate associations between the type of delivery (normal / cesarean section), the type of breastfeeding (maternal / artificial) and the dietary intake profile (onset and quality) with plasma short chain fatty acid concentrations in adult women with different levels of adiposity. METHODS: This is a scientific initiation project within the NutriHS study, which has been underway at UNICAMP since 2018. Its outline is cross-sectional, with a planned sample of 120 women, aged 18-45 years, with BMI between 18.5 to 39.9 kg / m 2. To date, 81 volunteers (67%) have been evaluated. The volunteers will respond to a semi-quantitative food frequency questionnaire to evaluate energy and fiber intake, validated for the adult population of the State of São Paulo and another questionnaire with questions related to birth to the second year of life. An anthropometric evaluation is performed to measure weight, height, and body circumferences. After a 12-hour fast, blood is collected to measure the concentration of short-chain fatty acids. PERSPECTIVES: The findings will contribute to elucidate which early life events were associated or not with a favorable profile of adiposity and short chain plasma fatty acids.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOLAR, ISABELA; RIBEIRO, FRANCIELI BARREIRO; BARBOSA, MARINA GOMES; FREITAS, RENATA GERMANO BORGES DE OLIVEIRA NASCIMENTO; HANADA, ALFREDO SHIGUEO; RAMOS, CAMILA DE OLIVEIRA; SANT'ANA, MARCELLA RAMOS; CANDREVA, THAMIRIS; DE ALMEIDA-PITITTO, BIANCA; TURA, ANDREA; et al. Short-chain fatty acids are associated with adiposity, energy and glucose homeostasis among different metabolic phenotypes in the Nutritionists' Health Study. ENDOCRINE, v. 80, n. 3, p. 12-pg., 2023-04-08. (17/10185-9, 19/07769-4, 17/24578-2, 19/05450-0)

BARBOSA, MARINA G.; SOLAR, ISABELA; FREITAS, RENATA G.; RIBEIRO, FRANCIELI B.; RAMOS, CAMILA O.; SANT'ANA, MARCELLA R.; HANADA, ALFREDO S.; CROUCHAN, NAJLA S. K.; XAVIER, CAMILA M.; NETO, BRUNO G.; et al. Fecal Profile of Short-Chain Fatty Acids: Associations with Environmental Factors in the First Year of Life of Women Participating in the Nutritionists Health Study. Diabetes, v. 69, p. 2-pg., 2020-06-01. (17/10185-9, 19/05450-0)