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BONEInk: synthesis and characterization of chitosan crosslinked with carbon nanotubes modified with RGD peptides and HA crystals for potential application of bioimpression of bone tissue

Grant number: 19/09735-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2019
Effective date (End): August 31, 2024
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Willian Fernando Zambuzzi
Grantee:João Paulo Ruiz Lucio de Lima Parra
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:14/22689-3 - Microvesicle/proteins-mediated paracrine signaling among bone and endothelial cells during bone development and regeneration, AP.JP
Associated scholarship(s):21/11291-2 - Development of osteoconductive/osteoinductive bone scaffolds using additive manufacturing techniques, BE.EP.DR


The increase in life expectancy and urban population concentrations have had serious consequences for the increase of accidents involving bone tissue, directly affecting the quality of life of these patients and increasing public spending in layers. Thus, it is necessary to develop methodologies and tools capable of contributing to this scenario, where tissue bioengineering brings together important ingredients, where our group has been working with the understanding of cellular responses to different biomaterials. In this scenario, proposing a biomaterial with autogenous bone properties to the patient represents an important step in it recovery, reducing its time in layer and alleviating the expenses. Without further ado, this action seeks to translate knowledge from basic research to the patient's bed, which is the end result of tissue bioengineering and regenerative medicine. Here, we celebrate the meeting of different knowledge in the proposition of a construct (BONEInk) with biological properties already predicted, potentially applied in 3D bio-printing of biomaterials. The articulation of the experience developed in Botucatu-SP with the National and International groups proposed here will guarantee the development of competences necessary to the group, as is the case of the materials characterization tools and biological performance of 3D bioprints. BONEInk will be developed from an association of a chitosan matrix cross-linked with carbon nanotubes, embedded with carbonated hydroxyapatite crystals and RGD peptides. We would like to point out that we are interested in requesting, in a timely manner, the complementary bag BEPE, for the sandwich stage in the United States in two stages. The evaluation of the effects of this product will be previously contemplated in critically sized injuries in rat calotte. Although the theme of this project was well explored in the literature, our motivation is precisely to know cellular and molecular aspects that govern its performance during regeneration mechanisms, as well as to propose previous protocols of synthesis/combinations, as an endpoint to propose new methodological alternatives to clinical practice, transferring knowledge and facilitating its application in bone tissue injuries, supported by a molecular repertoire that justifies its choice and performance, extremely necessary parameters for interfacing with the productive sector. Finally, we intend that this new routine can aggregate impact information in scientific articles and patents, as well as the acquisition of knowledge about related methodologies, not yet practiced in the Dep. Chemistry and Biochemistry, IBB-UNESP, through qualification of human resources. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, MURILLO L.; PINTO, THAIS S.; GOMES, ANDERSON M.; PARRA, JOAO P. R. L. L.; FRANCHI, JR., GILBERTO C.; ZAMBUZZI, WILLIAN F.; RODRIGUES, CLOVES G.. Immobilization of Paclitaxel on Hydroxyapatite for Breast Cancer Investigations. Langmuir, v. 36, n. 30, p. 8723-8732, . (19/09735-0, 14/22689-3)

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