|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||August 01, 2019|
|Effective date (End):||July 31, 2021|
|Field of knowledge:||Health Sciences - Nutrition - Nutrition Biochemistry|
|Principal researcher:||Bryan Saunders|
|Grantee:||Felipe Ribeiro Dainese Candido|
|Home Institution:||Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil|
Creatine (Cr) supplementation is an efficient strategy to increase intramuscular Cr and phosphoryilcreatine (PCr) content, which in turn has a key-role on energetic metabolism during high-intensity exercise. Based on this mechanism, creatine supplementation has been largely used as an ergogenic aid in sports, especially in conjunction with resistance training. However, some fundamental aspects inherent to supplementation protocols needs to be elucidated, particularly the role of timing of Cr ingestion on the adaptive responses to exercise. This study aims to investigate the influence of the timing of creatine supplementation during an exercise training program on body composition, muscle hypertrophy, strength, and intramuscular Cr and PCr content. This will be a randomized, double-blind, placebo-controlled study. Subjects will allocated into 3 possible groups according to the timing of the supplement ingestion, as follows: 1) Pre-training Cr/Post-training placebo; 2) Pre-training placebo/Post-training creatine; or 3) Pre-training placebo/post-training placebo. Concomitantly to the supplementation protocol, all subjects will perform an 8-week lower-limb resistance training program. Furthermore, it muscle strength, muscle cross-sectional area, and body composition will be evaluated. The findings from this study are of potential high impact from both scientific and practical standpoints, since they will optimize Cr prescription in sports and clinics.