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Influence of timing of creatine intake in relation to strength training on body composition, hypertrophy, and strength performance

Grant number: 18/19981-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2019
Effective date (End): July 31, 2021
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Bryan Saunders
Grantee:Felipe Ribeiro Dainese Candido
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Creatine (Cr) supplementation is an efficient strategy to increase intramuscular Cr and phosphoryilcreatine (PCr) content, which in turn has a key-role on energetic metabolism during high-intensity exercise. Based on this mechanism, creatine supplementation has been largely used as an ergogenic aid in sports, especially in conjunction with resistance training. However, some fundamental aspects inherent to supplementation protocols needs to be elucidated, particularly the role of timing of Cr ingestion on the adaptive responses to exercise. This study aims to investigate the influence of the timing of creatine supplementation during an exercise training program on body composition, muscle hypertrophy, strength, and intramuscular Cr and PCr content. This will be a randomized, double-blind, placebo-controlled study. Subjects will allocated into 3 possible groups according to the timing of the supplement ingestion, as follows: 1) Pre-training Cr/Post-training placebo; 2) Pre-training placebo/Post-training creatine; or 3) Pre-training placebo/post-training placebo. Concomitantly to the supplementation protocol, all subjects will perform an 8-week lower-limb resistance training program. Furthermore, it muscle strength, muscle cross-sectional area, and body composition will be evaluated. The findings from this study are of potential high impact from both scientific and practical standpoints, since they will optimize Cr prescription in sports and clinics.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PERIM, PEDRO; MARTICORENA, FELIPE MIGUEL; RIBEIRO, FELIPE; BARRETO, GABRIEL; GOBBI, NATHAN; KERKSICK, CHAD; DOLAN, EIMEAR; SAUNDERS, BRYAN. Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?. FRONTIERS IN NUTRITION, v. 6, AUG 27 2019. Web of Science Citations: 1.

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