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Microbiomes and immunobiological aspects in endodontic infections

Grant number: 19/14448-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): September 01, 2019
Effective date (End): October 31, 2023
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal Investigator:Brenda Paula Figueiredo de Almeida Gomes
Grantee:Erica Mendes Lopes
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated research grant:15/23479-5 - Microbiomes and immunobiological aspects in endodontic infections, AP.TEM

Abstract

More than 15 million endodontic (ET) treatments are performed annually in the US and also in Brazil due to endodontic infections (IE). These can cause signs and symptoms ranging from mild discomfort to serious life-threatening infections such as cellulite, angina or even death. This study aims to investigate the microbiomes present in different types of IE and the levels of LPS, LTA, MMP, substance P and inflammatory cytokines in the different clinical situations, in order to evaluate the effect of ET in reducing / eliminating the microbial / endotoxic content of root canals. The data obtained will be correlated with the clinical and radiographic aspects of the patients. It also aims to investigate the susceptibility of specific bacteria to the most used antibiotics in Endodontia, in order to obtain the current standard of susceptibility of the same. To this end, cutting-edge molecular methods such as Next Generation Sequencing will be used to assess the biodiversity of microbiomes; ELISA / cytometry to quantify the virulence factors and immunobiological aspects involved; and E-test / beta-lactamase production to obtain a profile of the susceptibility of specific bacteria to different antimicrobial agents. This work is innovative because it will evaluate high-technology methodologies, microbiomas, virulence factors and immunobiological aspects present in the different types of IE correlating them with the clinical and radiographic aspects of the patients, and will allow the monitoring of susceptibility and bacteria to the different antibiotics. All results will serve as the baseline for more effective ET elaboration. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES, ERICA M.; PASSINI, MAICON R. Z.; KISHI, LUCIANO T.; CHEN, TSUTE; PASTER, BRUCE J.; GOMES, BRENDA P. F. A.. Interrelationship between the Microbial Communities of the Root Canals and Periodontal Pockets in Combined Endodontic-Periodontal Diseases. MICROORGANISMS, v. 9, n. 9, . (15/23479-5, 19/14448-0)
GODOI-JR, EDERALDO P.; BRONZATO, JULIANA D.; FRANCISCO, PRISCILA A.; BICEGO-PEREIRA, ELOA C.; LOPES, ERICA M.; PASSINI, MAICON R. Z.; DE-JESUS-SOARES, ADRIANA; ALMEIDA, JOSE F. A.; MARCIANO, MARINA A.; FERRAZ, CAIO C. R.; et al. Microbiological profile of root canals indicated for endodontic retreatment due to secondary endodontic infections or for prosthetic reasons. CLINICAL ORAL INVESTIGATIONS, v. 27, n. 5, p. 16-pg., . (19/14448-0, 17/16516-7, 17/25090-3, 21/13871-6, 21/14570-0)
CHIARELLI-NETO, VITO M.; DE AVEIRO, EMELLY; BRONZATO, JULIANA D.; ARRUDA-VASCONCELOS, RODRIGO; LOUZADA, LIDIANE M.; GODOI, EDERALDO P.; LOPES, ERICA M.; DE-JESUS-SOARES, ADRIANA; FERRAZ, CAIO C. R.; ALMEIDA, JOSE F. A.; et al. Clinical evaluation of culturable bacteria, endotoxins and lipoteichoic acid in teeth with vital normal pulp tissues. AUSTRALIAN ENDODONTIC JOURNAL, v. N/A, p. 9-pg., . (21/13871-6, 15/23479-5, 19/14448-0, 21/14570-0, 17/25242-8, 17/25090-3, 19/19300-0)

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