Acute inflammatory response to moderate-intensity continuous and high-intensity interval training: role to toll-like receptor 4

• Grant number: 18/17648-7
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: November 30, 2019
• End date: November 29, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fábio Santos de Lira
• Grantee: Carolina Cabral Santos
• Supervisor: Jonathan Peter Little
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Institution abroad: University of British Columbia, Okanagan (UBC), Canada
• Associated to the scholarship: 15/26148-0 - Role of toll like receptor 4 (TLR-4) in lipolytic response mediated by acute exhaustive exercise, BP.DR

Abstract

In the present study, we aim to investigate the effects of short-term exercise (2 weeks) on the acute regulation of the expression of several cytokines that possess anti-inflammatory properties including interleukin-6 (IL-6) and interleukin-10 (IL-10) and the underlying mechanism involving signal transducer and activator of transcription protein (STAT3) and toll-like receptor 4 (TLR-4). Thirty inactive adults will be randomized to two groups of high-intensity interval exercise (HIIT) or moderate-intensity continuous training (MICT). To examine whether exercise is accompanied by inflammatory response and if the inflammation status is reversed by training adaptation, lipopolysaccharide (LPS)-induced tumour necrosis factor (TNF)-± production will be measured in whole blood cultures in the presence or absence of IL-6 or IL-10. Anti-inflammatory IL6/IL10 signalling and pro-inflammatory signalling through TLR-4 will be analysed by flow cytometry analysis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CABRAL-SANTOS, CAROLINA; RAFIEI, HOSSEIN; LIRA, FABIO S.; LITTLE, JONATHAN P.. Acute Inflammatory Response of Breaking Up Prolonged Sitting with Stair Climbing Exercise Snacks. Diabetes, v. 70, p. 2-pg., 2021-06-01. (18/17648-7)

CABRAL-SANTOS, CAROLINA; SILVEIRA, LOREANA SANCHES; CHIMIN, PATRICIA; ROSA-NETO, JOSE CESAR; LIRA, FABIO SANTOS. Moderate aerobic exercise-induced cytokines changes are disturbed in PPAR alpha knockout mice. CYTOKINE, v. 134, p. 7-pg., 2020-10-01. (18/17648-7, 15/26148-0, 14/01246-6)