Scholarship 19/17426-7 - Própolis, Própolis vermelha - BV FAPESP
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Change of isoflavonoid pattern in Brazilian red propolis after dynamic gastrointestinal digestion and transport by Caco-2 cells

Grant number: 19/17426-7
Support Opportunities:Scholarships abroad - Research
Start date until: January 10, 2020
End date until: January 09, 2021
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Severino Matias de Alencar
Grantee:Severino Matias de Alencar
Host Investigator: Fanbin Kong
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Institution abroad: University of Georgia, Athens (UGA), United States  

Abstract

Brazil is a major producer and exporter of propolis of Apis mellifera L. A new type of Brazilian propolis, named red propolis, has been chemically and biologically characterized by our research group. A peculiar phenolic composition was found in this type of propolis, mainly isoflavonoids, in addition to antioxidant, antimicrobial, and anti-inflammatory activities. Based on the evidence that the consumption of these phytoestrogens has beneficial effects such as the positive impact on menopause discomfort, foods containing isoflavonoids of red propolis represent a potential and promising market. Moreover, their bioaccessibility and epithelial transport by human cells have never been given attention in order to clarify whether the isoflavonoids present in this type of propolis are modified during these steps, and whether the antioxidant properties observed in ethanol extracts of propolis are conserved. Thus, the bioacessibility study of isoflavonoids of Brazilian red propolis after dynamic gastrointestinal digestion and their transport by human intestinal epithelial Caco-2 cells opens new paths to add value and develop new functional ingredients and products, since Brazil currently exports this type of propolis exclusively as raw material. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE ALENCAR, SEVERINO MATIAS; SARTORI, ALAN GIOVANINI DE OLIVEIRA; DAG, DAMLA; BATISTA, POLLYANNA SOUZA; ROSALEN, PEDRO LUIZ; IKEGAKI, MASAHARU; KONG, FANBIN. Dynamic gastrointestinal digestion/intestinal permeability of encapsulated and nonencapsulated Brazilian red propolis: Active compounds stability and bioactivity. Food Chemistry, v. 411, p. 9-pg., . (19/11248-0, 19/17426-7)
FRANCHIN, MARCELO; SALIBA, ANA SOFIA MARTELLI CHAIB; SARTORI, ALAN GIOVANINI DE OLIVEIRA; NETO, SEBASTIAO ORESTES PEREIRA; BENSO, BRUNA; IKEGAKI, MASAHARU; WANG, KAI; ALENCAR, SEVERINO MATIAS DE; GRANATO, DANIEL. Food-grade delivery systems of Brazilian propolis from Apis mellifera: From chemical composition to bioactivities in vivo. Food Chemistry, v. 432, p. 14-pg., . (19/11248-0, 19/17721-9, 19/17426-7)

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