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Morphoquantitative evaluation of the rat (Rattus Norvegicus) kidney after cryopreservation: advances for the organs bank

Grant number: 19/11425-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): June 30, 2020
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Tais Harumi de Castro Sasahara
Grantee:Jacqueline dos Santos da Silva
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Chronic renal disease occurs frequently in domestic animals, characterized by the decrease or loss of renal function, such as filtration, erythropoiesis, acidic and basic control, hydroelectrolytic, and may be of hereditary, congenital, infectious, toxic, among others. The number of kidney transplants has increased significantly in recent years, with much greater demand than is necessary to serve the population. In this way, cryopreservation is an organ preservation option to supply organ and tissue banks, reduce waste and increase the effective number of transplants. Thus, morphological and quantitative data are useful to evaluate the degree of preservation and damage in the renal tissue, aiming, therefore, to improve protocols for conservation at low temperatures. The objective of this study was to evaluate the renal tissue of rats submitted to cryopreservation by qualitative and quantitative analysis, based on stereological methods, more efficient and accurate. (AU)