Promotion of healthy lifestyle in patients with Systemic Lupus Erythematosus: assessment of safety, efficiency and feasibility of the study `vivendo bem com Lúpus´ (living well with Lupus)

• Grant number: 19/14819-8
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): March 01, 2020
• Effective date (End): February 29, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal researcher: Bruno Gualano
• Grantee: Fabiana Infante Smaira
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Patients with Systemic Lupus Erythematosus spend most of their daily hours in sedentary behavior and tend to be inactive. Sedentary behavior and physical inactivity are independent risk factors for poorer markers of health and mortality in the general population and in clinical cases. In addition, the food pattern is a determining factor in the individuals' health. Due to the lack of studies on the dietary pattern of patients with Systemic Lupus Erythematosus, it is believed that these patients present the same feeding profile of the general population, which is, high consumption of foods with unbalanced nutritional composition and high caloric density, characterized by an inadequate supply of micronutrients. In this context, new interventions focused on the practice of physical activity and food consumption management would be of great therapeutic relevance. However, to date, there are no studies focused on these strategies in patients with Systemic Lupus Erythematosus. Therefore, it is fundamental to evaluate the lifestyle changes resulting from a new intervention proposal. Thence, this project aims to: assess the safety, efficacy, and viability of clinical intervention, as well as the barriers and facilitators for engagement in lifestyle changes. It is a randomized, parallel group, controlled clinical study in which the following pre and post-intervention data will be collected: 1) sedentary behavior parameters and level of physical activity; 2) eating habits; 3) clinical parameters; 4) safety parameters and intervention feasibility. In addition, focus groups will be carried out at the end of the follow-up in order to qualitatively assess the impacts of the intervention. The findings of this project will be of great clinical relevance once they can serve as a basis for new prescriptions focused on the change of food and physical activity habits, which are risk factors for patients with Lupus. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIECZKOWSKA, MENDES; SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; GUALANO, BRUNO; ROSCHEL, HAMILTON; PECANHA, TIAGO. Efficacy of home-based physical activity interventions in patients with autoimmune rheumatic diseases: A systematic review and meta-analysis. SEMINARS IN ARTHRITIS AND RHEUMATISM, v. 51, n. 3, p. 576-587, JUN 2021. Web of Science Citations: 0.

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; ESTEVES, GABRIEL PERRI; ANDRE, HELOISA C. SANTO; AMARANTE, MILLA CORDEIRO; CASTANHO, DANIELA FERNANDES; CAMPOS, KAREN JENNIFER DE; BENATTI, FABIANA BRAGA; PINTO, ANA JESSICA; ROSCHEL, HAMILTON; GUALANO, BRUNO; NICOLETTI, CAROLINA FERREIRA. Poor Eating Habits and Selected Determinants of Food Choice Were Associated With Ultraprocessed Food Consumption in Brazilian Women During the COVID-19 Pandemic. FRONTIERS IN NUTRITION, v. 8, MAY 13 2021. Web of Science Citations: 0.

PECANHA, TIAGO; MEIRELES, KAMILA; PINTO, ANA JESSICA; NUNES REZENDE, DIEGO AUGUSTO; IRAHA, AMANDA YURI; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; KLUSER SALES, ALLAN ROBSON; BONFIGLIOLI, KARINA; DE SA-PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; IRIGOYEN, MARIA CLAUDIA; GUALANO, BRUNO; ROSCHEL, HAMILTON. Increased sympathetic and haemodynamic responses to exercise and muscle metaboreflex activation in post-menopausal women with rheumatoid arthritis. JOURNAL OF PHYSIOLOGY-LONDON, v. 599, n. 3 NOV 2020. Web of Science Citations: 3.