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Promotion of healthy lifestyle in patients with Systemic Lupus Erythematosus: assessment of safety, efficiency and feasibility of the study `vivendo bem com Lúpus´ (living well with Lupus)

Grant number: 19/14819-8
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2020
Effective date (End): February 29, 2024
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Bruno Gualano
Grantee:Fabiana Infante Smaira
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Patients with Systemic Lupus Erythematosus spend most of their daily hours in sedentary behavior and tend to be inactive. Sedentary behavior and physical inactivity are independent risk factors for poorer markers of health and mortality in the general population and in clinical cases. In addition, the food pattern is a determining factor in the individuals' health. Due to the lack of studies on the dietary pattern of patients with Systemic Lupus Erythematosus, it is believed that these patients present the same feeding profile of the general population, which is, high consumption of foods with unbalanced nutritional composition and high caloric density, characterized by an inadequate supply of micronutrients. In this context, new interventions focused on the practice of physical activity and food consumption management would be of great therapeutic relevance. However, to date, there are no studies focused on these strategies in patients with Systemic Lupus Erythematosus. Therefore, it is fundamental to evaluate the lifestyle changes resulting from a new intervention proposal. Thence, this project aims to: assess the safety, efficacy, and viability of clinical intervention, as well as the barriers and facilitators for engagement in lifestyle changes. It is a randomized, parallel group, controlled clinical study in which the following pre and post-intervention data will be collected: 1) sedentary behavior parameters and level of physical activity; 2) eating habits; 3) clinical parameters; 4) safety parameters and intervention feasibility. In addition, focus groups will be carried out at the end of the follow-up in order to qualitatively assess the impacts of the intervention. The findings of this project will be of great clinical relevance once they can serve as a basis for new prescriptions focused on the change of food and physical activity habits, which are risk factors for patients with Lupus. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Social distancing has changed Brazilian women’s eating habits, study shows 
Articles published in other media outlets (17 total):
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Estado de Minas: Dias mais saborosos e especiais (13/Dec/2020)
Estado de Minas online: Cozinhar pode resultar em dias mais saborosos e especiais (13/Dec/2020)
UOL: Isolamento social modifica a alimentação das brasileiras, aponta pesquisa (20/Nov/2020)
Folha.com: Isolamento social modificou comportamento alimentar das mulheres brasileiras, revela estudo (19/Nov/2020)
A Tribuna (Santos, SP) online: Comportamento alimentar das mulheres mudou na quarentena (24/Nov/2020)
Portal São José dos Campos: Isolamento social modifica o comportamento alimentar das mulheres brasileiras, revela estudo da USP (24/Nov/2020)
O Sul: O isolamento social muda o comportamento alimentar de brasileiras (23/Nov/2020)
O Sul online: O isolamento social muda o comportamento alimentar de brasileiras (22/Nov/2020)
Nuttrisaude: Isolamento social muda comportamento alimentar de brasileiras (22/Nov/2020)
ABCD Real: Isolamento social muda comportamento alimentar das mulheres brasileiras, mostra estudo (22/Nov/2020)
Plantão News (MT): Isolamento social modifica o comportamento alimentar das mulheres brasileiras, revela estudo (21/Nov/2020)
Dom Total: Comportamento alimentar de mulheres brasileiras mudou com o isolamento social (21/Nov/2020)
MSN: Isolamento social muda comportamento alimentar de brasileiras (20/Nov/2020)
MSN: Isolamento social modifica o comportamento alimentar das mulheres brasileiras, revela estudo (20/Nov/2020)
Planeta online: Isolamento social muda comportamento alimentar de brasileiras (20/Nov/2020)
Revista Pará: Isolamento social modifica o comportamento alimentar das mulheres brasileiras (20/Nov/2020)
Portal da Enfermagem: Isolamento social modifica o comportamento alimentar das mulheres brasileiras (20/Nov/2020)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PECANHA, TIAGO; MEIRELES, KAMILA; PINTO, ANA JESSICA; NUNES REZENDE, DIEGO AUGUSTO; IRAHA, AMANDA YURI; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; KLUSER SALES, ALLAN ROBSON; BONFIGLIOLI, KARINA; DE SA-PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; IRIGOYEN, MARIA CLAUDIA; GUALANO, BRUNO; ROSCHEL, HAMILTON. Increased sympathetic and haemodynamic responses to exercise and muscle metaboreflex activation in post-menopausal women with rheumatoid arthritis. JOURNAL OF PHYSIOLOGY-LONDON, v. 599, n. 3 NOV 2020. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.