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Effect of the addition of de ²-lycerophosphate calcium nanoparticles on fluoride toothpastes on the remineralization of caries lesions: in situ study

Grant number: 19/16106-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2020
Effective date (End): May 31, 2021
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Marcelle Danelon
Grantee:Julia Paião Quinteiro
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The objective of this project will be to evaluate in situ the effect of microparticulate ²-CaGP (²-CaGPm) and nanoparticulate (²-CaGPn) added to conventional toothpastes (1100 ppm F) on the process of remineralization of initial caries lesions. Blocks (n = 192) of bovine teeth will be selected through initial surface hardness (SH), after which they will be submitted to the induction of artificial caries lesion for 16 hours. The post-demineralization surface hardness (SH1) will be determined. This study will be double blind and crossed, performed in 4 experimental phases with duration of 3 days each, and washout of 7 days. Volunteers (n = 12) will use palatine devices containing 4 blocks of bovine enamel with artificial caries lesion. The treatment regimens will be: 1) Toothpaste without F/²-CaGPm/²-CaGPn (Placebo); 2) Toothpaste 1100 ppm F (1100F); 3) Toothpaste 1100 ppm associated with 0.5% ²-CaGPm (1100F- 0.5% ²-CaGPm) and 4) Toothpaste 1100 ppm associated with 0.25% ²-CaGPn (1100F-0.25% ²-CaGPn ). The volunteers will be instructed to brush the natural teeth with the palatal devices in the oral cavity, the blocks being treated with the slurry of the toothpaste for 1 minute and 30 seconds (3x/day). After the experimental period the final surface hardness (SH2) will be determined for the calculation of the percentage of surface hardness recovery (%SHR). The data will be submitted to normality and homogeneity tests to use the statistical test most appropriate to the data distribution. Sigmaplot© software statistical software for Windows version 12.0 will be used, with significance at the 5% level.

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