Interaction of microorganisms and human hosts associated with the clinical outcome of patients with infectious diseases

• Grant number: 20/05284-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: October 01, 2020
• End date: March 29, 2025
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Helder Takashi Imoto Nakaya
• Grantee: Ícaro Maia Santos de Castro
• Host Institution: Centro de Inovação da USP (INOVA). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/14933-2 - Integrative biology applied to human health, AP.JP2
• Associated scholarship(s): 23/03951-8 - A metatranscriptomics pipeline to investigate host-microbe interactions in low-biomass samples: a case study in liquid biopsies from prostate cancer patients, BE.EP.DD

Abstract

In recent years the importance of studying the communities of microorganisms present in the human intestine has been widely elucidated. These microbial communities not only contribute to the hosts local defense against infections, but theyalso modulate immune system responses in different sites and tissues. The human microbiome is dynamic, and under conditions that compromise the host defense barrier, some species of these microorganisms can invade tissues and cause viral, bacterial, and fungal infections. Our study aims to investigate the impact of gene expression and the host microbiome on the immunological response during several infectious diseases. Through public RNA-seq data from human blood samples, we intend to perform a multi-integrative approach through systems biology to elucidate how the interaction of host microbiome and host immunological system can impact the clinical outcome of patients affected by infectious diseases. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AQUIME GONCALVES, ANDRE NICOLAU; MASO, VANESSA ESCOLANO; SANTOS DE CASTRO, ICARO MAIA; VASCONCELOS, AMANDA PEREIRA; TOMIO OGAVA, RODRIGO LUIZ; NAKAYA, HELDER, I. High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, v. N/A, n. 181, p. 22-pg., 2022-03-01. (18/14933-2, 13/08216-2, 19/13880-5, 19/16418-0, 19/27146-1, 12/19278-6, 20/05284-0, 17/50137-3, 18/21934-5)