Increase of antimicrobial potential of acid lactic bacteria over Salmonella Heidelberg through bacterial comunication

• Grant number: 20/12843-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): March 01, 2021
• Effective date (End): December 31, 2021
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Adriano Sakai Okamoto
• Grantee: Gabriella Costa Ribeiro
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

According to the Brazilian Animal Protein Association, in 2019, Brazil ranked 1st in chicken meat exports. Thus, microbiological challenges on production have increased, among them, water and foodborne diseases, especially salmonellosis. Thus, in order to prevent colonization of the intestinal mucosa by enteropathogens, products with the function of modulating the bird's intestinal microbiota, such as probiotics, mainly composed of lactic acid bacteria (BALs) were developed. In addition to direct antagonism to salmonella, BALs exercise a mechanism of bacterial communication, which impels the intestinal microbiota to collectively inhibit the pathogen. Upon reaching a minimum population density, this behavior is triggered, leading to recognition and secretion of inducing peptides. In this context, the objective of this study will be to evaluate the potentiation of Salmonella Heidelberg inhibition by a reference strain of Lactobacillus salivarius ATCC 1174, and by other BALs (Lactobacillus, Enterococcus, Pediococcus e Lactococcus), modulated by peptides that induces bacterial communication.