Contribution of sepiapterin redutacse in the melanoma migration and invasion processes

• Grant number: 21/04260-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2021
• End date: August 31, 2022
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Fabiana Henriques Machado de Melo
• Grantee: Fernanda Oliveira dos Santos
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The incidence of cutaneous melanoma has been increasing in recent years due to increased life expectancy and increased exposure to ultraviolet rays. Melanoma is an extremely aggressive cancer, with a high rate of metastases and consequently high mortality. Late diagnosis, lack of tumor markers, and the inefficiency of available therapies are the main factors associated with high lethality. The high proliferative capacity of melanoma cells is associated with the alteration of innumerable molecules, among them, growth factors, signaling proteins, and cell cycle regulators. Recently, the action of the sepiapterin reductase enzyme on the development and proliferation of neuroblastoma, hepatocellular carcinoma, and breast cancer has been described, the results suggest that this protein contributes to the development of these cancers. Data from our laboratory showed a progressive increase in sepiapterin reductase expression along with the progression of melanoma, suggesting that this enzyme contributes to the development of the disease. As we observed a greater amount of sepiapterin reductase in the metastatic melanoma strains, the objective of this work is to evaluate the role of sepiapterin reductase in characteristics acquired by more aggressive melanoma cells such as migration and invasion. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOURA SOARES, JAQUELINE PEREIRA; GONCALVES, DIEGO ASSIS; DE SOUSA, RICARDO XISTO; MOURO, MARGARETH GORI; HIGA, ELISA M. S.; SPERANDIO, LETICIA PAULINO; VITORIANO, CAROLINA MORAES; SANTA ROSA, ELISA BACHIR; DOS SANTOS, FERNANDA OLIVEIRA; DE QUEIROZ, GUSTAVO NERY; et al. Disruption of Redox Homeostasis by Alterations in Nitric Oxide Synthase Activity and Tetrahydrobiopterin along with Melanoma Progression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 11, p. 20-pg., 2022-06-01. (17/04352-0, 21/12988-7, 17/10695-7, 21/04260-3, 19/27517-0)