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Contribution of sepiapterin redutacse in the melanoma migration and invasion processes

Grant number: 21/04260-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2021
Effective date (End): August 31, 2022
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal researcher:Fabiana Henriques Machado de Melo
Grantee:Fernanda Oliveira dos Santos
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The incidence of cutaneous melanoma has been increasing in recent years due to increased life expectancy and increased exposure to ultraviolet rays. Melanoma is an extremely aggressive cancer, with a high rate of metastases and consequently high mortality. Late diagnosis, lack of tumor markers, and the inefficiency of available therapies are the main factors associated with high lethality. The high proliferative capacity of melanoma cells is associated with the alteration of innumerable molecules, among them, growth factors, signaling proteins, and cell cycle regulators. Recently, the action of the sepiapterin reductase enzyme on the development and proliferation of neuroblastoma, hepatocellular carcinoma, and breast cancer has been described, the results suggest that this protein contributes to the development of these cancers. Data from our laboratory showed a progressive increase in sepiapterin reductase expression along with the progression of melanoma, suggesting that this enzyme contributes to the development of the disease. As we observed a greater amount of sepiapterin reductase in the metastatic melanoma strains, the objective of this work is to evaluate the role of sepiapterin reductase in characteristics acquired by more aggressive melanoma cells such as migration and invasion. (AU)

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